CoraLite® Plus 488-conjugated Ataxin 2 Monoclonal antibody

Ataxin 2 Monoclonal Antibody for IF-P

Host / Isotype

Mouse / IgM

Reactivity

Human, Mouse, Rat

Applications

IF-P

Conjugate

CoraLite® Plus 488 Fluorescent Dye

CloneNo.

1E8A2

Cat No : CL488-68316

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Synonyms

ataxin 2, ATX2, ATXN2, FLJ46772, SCA2, TNRC13



经过测试的应用

Positive IF detected inrat brain tissue
For other applications, we recommend the unconjugated version of this antibody, 68316-1-Ig

推荐稀释比

ApplicationDilution
Immunofluorescence (IF)IF : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

CL488-68316 targets Ataxin 2 in IF applications and shows reactivity with Human, Mouse, Rat samples.

Tested Applications IF-P
Tested Reactivity Human, Mouse, Rat
Immunogen Ataxin 2 fusion protein Ag17402 种属同源性预测
Host / Isotype Mouse / IgM
Class Monoclonal
Type Antibody
Full Name ataxin 2
Synonyms ataxin 2, ATX2, ATXN2, FLJ46772, SCA2, TNRC13
Calculated Molecular Weight 1313 aa, 140 kDa
Observed Molecular Weight140-150 kDa
GenBank Accession NumberBC114546
Gene Symbol ATXN2
Gene ID (NCBI) 6311
Conjugate CoraLite® Plus 488 Fluorescent Dye
Excitation/Emission Maxima Wavelengths493 nm / 522 nm
Form Liquid
Purification MethodCaprylic acid/ammonium sulfate precipitation
UNIPROT IDQ99700
Storage Buffer PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3.
Storage ConditionsStore at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

ATXN2 contains a repeat structure with 22 or 23 triplets coding for glutamine and the (CAG)8CAA(CAG)4CAA(CAG)8 sequence; expansion of this domain to a size ≥34 triplets with a pure CAG sequence primarily causes autosomal dominant SCA2 [PMID:18418684], while ATXN2 expansions with CAA interruptions were observed as the cause of Levo-dopa responsive Parkinson's disease [PMID:10668726]. ATXN2 expansions associated with ALS were reported to be interrupted by at least one CAA triplet [PMID:21537950]

实验方案

Product Specific Protocols
IF protocol for CL Plus 488 Ataxin 2 antibody CL488-68316Download protocol
Standard Protocols
Click here to view our Standard Protocols