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验证数据展示

  • FC experiment of Transfected CKO-K1 using 98529-1-RR (same clone as 98529-1-PBS)

    FC experiment of Transfected CKO-K1 using 98529-1-RR (same clone as 98529-1-PBS)

    1x10^6 CKO-K1(left) or ACE2-transfected CKO-K1(right) were surface stained with 0.25 ug Anti-Human ACE2 Rabbit RecAb (98529-1-RR, Clone:250363F10) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed and permeabilized with Intracellular Flow Cytometry Fixation & Permeabilization Buffer Kit (PF00019). This data was developed using the same antibody clone with 98529-1-PBS in a different storage buffer formulation.

  • FC experiment of Calu-3 using 98529-1-RR (same clone as 98529-1-PBS)

    FC experiment of Calu-3 using 98529-1-RR (same clone as 98529-1-PBS)

    1x10^6 Calu-3 cells(left) or Hela cells(right) were surface stained with 0.25 ug Anti-Human ACE2 Rabbit RecAb (98529-1-RR, Clone:250363F10)(red), or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue) and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were fixed and permeabilized with Intracellular Flow Cytometry Fixation & Permeabilization Buffer Kit (PF00019). This data was developed using the same antibody clone with 98529-1-PBS in a different storage buffer formulation.

  • Affinity of 98529-1-RR

    Affinity of 98529-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98529-1-RR against Human ACE2 were performed. The affinity constant is 0.962 nM.

Anti-Human ACE2 Rabbit Recombinant Antibody, PBS Only

ACE2 Uni-rAb® Recombinant Antibody for FC
Cat No. 98529-1-PBS

产品说明书

CloneNo. 250363F10

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

ACE related carboxypeptidase, ACEH, ACE-related carboxypeptidase, Angiotensin converting enzyme 2, Angiotensin-converting enzyme 2

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy ACE2 Ready-To-Use IHC Kit. ACE2 primary antibody included.

产品信息

98529-1-PBS targets ACE2 in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原

CatNo: Eg0074

Product name: Recombinant Human ACE2 protein (His Tag)

Source: mammalian cells-derived, pHZ-KIsec

Tag: N-6*His

Domain: 18-740 aa of BC048094

Sequence: QSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
别名 ACE related carboxypeptidase, ACEH, ACE-related carboxypeptidase, Angiotensin converting enzyme 2, Angiotensin-converting enzyme 2
计算分子量 805 aa, 92 kDa
GenBank蛋白编号BC048094
基因名称 ACE2
Gene ID (NCBI) 59272
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ9BYF1
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

ACE2 (Angiotensin-converting enzyme 2), also named as ACEH, is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE, being found predominantly in the heart, kidneys, and testes although low levels have been detected in a variety of tissues (PMID:15983030). ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2 (PMID: 32142651). The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility, symptoms, and outcome of 2019-nCoV/SARS-CoV-2 infection (PMID: 32133153). It can be used as a potential therapeutic target of SARS-CoV-2 (PMID: 32125455).

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