验证数据展示
产品信息
98824-2-PBS targets uPA/Urokinase in FC applications and shows reactivity with human samples.
| 经测试应用 | FC Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Eg7083 Product name: Recombinant human PLAU/uPA protein Source: mammalian cells-derived, pHZ-KIsec-C-rFc Tag: C-rFc Domain: 21-431 aa of NM_002658.6 Sequence: SNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQHCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNRRRPWCYVQVGLKLLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLGRSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIRSHTKEENGLAL 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | plasminogen activator, urokinase |
| 别名 | PLAU, UPA, ATF, EC:3.4.21.73, u PA |
| 计算分子量 | 49kDa |
| GenBank蛋白编号 | NM_002658.6 |
| 基因名称 | Urokinase |
| Gene ID (NCBI) | 5328 |
| RRID | AB_3746365 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P00749-1 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
uPA (Urokinase-type plasminogen activator) is also named as Urokinase or PLAU, and belongs to the peptidase S1 family. uPA initiates a proteolytic cascade, which degrades the extracellular matrix during tissue growth and remodelling. The secreted proform of uPA is activated after binding to a specific high-affinity cell surface receptor. Secreted UPA is exposed to rapid inactivation in the pericellular space by plasminogen activator inhibitor-1 (PAI-1), which is stored in the extracellular matrix bound to vitronectin (PMID: 9665342). It has 2 isoforms produced by alternative splicing. Defects in uPA are the cause of Quebec platelet disorder (QPD).
