Validation Data Gallery
Technical Specifications
| GeneID | 3440 |
| Species | Human |
| Expression | HEK293 |
| Activity | Typically ≤ 0.12 ng/mL |
| Specific Activity | minimally 5.00 x 107 IU/mg |
| Purity | >95% |
| Endotoxin | <1 EU/μg |
| Accession Number | P01563 |
| Molecular Mass | 18 to 22 kDa reduced, 16 to 18 kDa non-reduced, monomer, glycosylated |
| Formulation | 1x PBS, See Certificate of Analysis for details |
| Species Reactivity | human |
Stability and Reconstitution
| Stability and Storage | Product Form | Temperature Conditions | Storage Time (From Date of Receipt) |
|---|---|---|---|
| Lyophilized | -20°C to -80°C | Until Expiry Date | |
| Lyophilized | Room Temperature | 2 weeks | |
| Reconstituted as per CofA | -20°C to -80°C | 6 months | |
| Reconstituted as per CofA | 4°C | 1 week | |
| Avoid repeated freeze-thaw cycles. | |||
| Reconstitution | Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein to 0.2 mg/mL in sterile 1x PBS pH 7.4 containing 0.1% endotoxin-free recombinant human serum albumin (HSA). Gently swirl or tap vial to mix. |
Background
Interferon alpha 2 is a type 1 interferon secreted by virus-infected cells to protect surrounding cells from the pathogen. Recombinant human interferon alpha 2 has been approved for therapeutic application in a range of human oncological and viral diseases. Three Interferon alpha 2 subvariants (2A, 2B, 2C) differ by only one or two amino acids at positions 23 and/or 34 of the mature protein (PMID: 25982860; 10672347; 1694761)
Synonyms
IFN alpha 2, IFNA, IFNA2, INFA2, Interferon alpha 2, Interferon alpha A, interferon, alpha 2, LeIF A
Publications
| Species | Title |
|---|---|
Cancer Sci Combination of tumor necrosis factor-α and epidermal growth factor induces the adrenergic-to-mesenchymal transdifferentiation in SH-SY5Y neuroblastoma cells. | |
Antiviral Res Antiviral candidates against the hepatitis E virus (HEV) and their combinations inhibit HEV growth in in vitro. | |
EMBO Mol Med SLE serum induces altered goblet cell differentiation and leakiness in human intestinal organoids | |
Cell Rep Methods Generation, expansion, gene delivery, and single-cell profiling in rhesus macaque plasma B cells | |
Mol Ther Targeting human plasma cells using small molecule regulated BCMA CAR T cells eliminates circulating antibodies in humanized mice |