验证数据展示
产品信息
25556-1-PBS targets ZNF695 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag22202 Product name: Recombinant human ZNF695 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 88-133 aa of BC023527 Sequence: LSSYLTEDILPEQGLQVSFQKVMLRRYERCCLEKLRLRNDWEIVAM 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | zinc finger protein 695 |
| 别名 | SBZF3 |
| 计算分子量 | 515 aa, 60 kDa |
| 观测分子量 | 43 kDa |
| GenBank蛋白编号 | BC023527 |
| 基因名称 | ZNF695 |
| Gene ID (NCBI) | 57116 |
| RRID | AB_2880130 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q8IW36 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
ZNF695 is a KRAB-containing zinc finger transcription factor localized in the nucleus. It binds DNA and mediates transcriptional repression, and its dysregulation participates in tumor progression across multiple malignancies. Elevated ZNF695 promotes cancer cell proliferation, accelerates cell cycle and suppresses apoptosis by activating NEK2 and PI3K/Akt/mTOR pathways. It acts as a prognostic biomarker correlated with tumor immune infiltration in colorectal, cervical, breast and endometrial cancers. Its expression varies among tumor subtypes, associating with aggressive tumor phenotypes (PMID: 38441026; PMID: 40682845).
