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验证数据展示

  • WB analysis using 13919-1-AP (same clone as 13919-1-PBS)

    WB analysis using 13919-1-AP (same clone as 13919-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 13919-1-AP (VILIP-1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13919-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse brain using 13919-1-AP (same clone as 13919-1-PBS)

    IP experiment of mouse brain using 13919-1-AP (same clone as 13919-1-PBS)

    IP result of anti-VILIP-1 (IP:13919-1-AP, 3ug; Detection:13919-1-AP 1:1000) with mouse brain tissue lysate 2640ug. This data was developed using the same antibody clone with 13919-1-PBS in a different storage buffer formulation.

  • WB analysis of HepG2 using 13919-1-AP (same clone as 13919-1-PBS)

    WB analysis of HepG2 using 13919-1-AP (same clone as 13919-1-PBS)

    WB result of VILIP1 antibody (13919-1-AP; 1:3000; incubated at room temperature for 1.5 hours) with sh-Control and sh-VILIP1 transfected HepG2 cells. This data was developed using the same antibody clone with 13919-1-PBS in a different storage buffer formulation.

  • IHC staining of Human bowens disease using 13919-1-AP (same clone as 13919-1-PBS)

    IHC staining of Human bowens disease using 13919-1-AP (same clone as 13919-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human brown disease slide using 13919-1-AP (VILIP-1 antibody) at dilution of 1:2000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13919-1-PBS in a different storage buffer formulation.

  • IF Staining of HeLa using 13919-1-AP (same clone as 13919-1-PBS)

    IF Staining of HeLa using 13919-1-AP (same clone as 13919-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HeLa cells using VILIP-1 antibody (13919-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 13919-1-PBS in a different storage buffer formulation.

VILIP1 Polyclonal antibody, PBS Only

VILIP1 Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 13919-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IF/ICC, IP, Indirect ELISA

别名

VILIP 1, VILIP-1, VSNL1, Hippocalcin like protein 3, Hippocalcin-like protein 3

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

13919-1-PBS targets VILIP1 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag4923

Product name: Recombinant human VSNL1 protein

Source: e coli.-derived, T-HIS

Tag: 6*His

Domain: 1-191 aa of BC022012

Sequence: MGKQNSKLAPEVMEDLVKSTEFNEHELKQWYKGFLKDCPSGRLNLEEFQQLYVKFFPYGDASKFAQHAFRTFDKNGDGTIDFREFICALSITSRGSFEQKLNWAFNMYDLDGDGKITRVEMLEIIEAIYKMVGTVIMMKMNEDGLTPEQRVDKIFSKMDKNKDDQITLDEFKEAAKSDPSIVLLLQCDIQK

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 visinin-like 1
别名 VILIP 1, VILIP-1, VSNL1, Hippocalcin like protein 3, Hippocalcin-like protein 3
计算分子量 22 kDa
观测分子量 18-24 kDa
GenBank蛋白编号BC022012
基因名称 VSNL1
Gene ID (NCBI) 7447
RRIDAB_2215851
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP62760
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Visinin-like protein 1 (VILIP1) is also named VLP-1, hippocalcin-like protein 3 (HLP3), VSNL1 and VISL1. The neuronal calcium sensor protein VILIP1 forms a complex with neurotransmitter-gated P2X2 receptors, functions as a channel regulator, and likely binds more tightly to P2X2 receptors in an activation- and calcium-dependent manner (PMID: 18922787). VILIP1 is widely expressed and involved in physiological and disease processes throughout the body, including tumor formation (PMID: 17311005, PMID: 18301774). VILIP1 is localized primarily in the rat hippocampus, where it controls neuronal excitability important for learning and memory (PMID: 18440708, PMID: 15336574). In particular, VILIP1 binds to the α-subunit of the α4β2 nicotinic acetylcholine receptor (nAChR), which promotes its surface expression and trafficking in oocytes and hippocampal neurons (PMID: 1220248, PMID: 19063970).

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