CoraLite® Plus 488-conjugated VEGFR2/KDR Monoclonal antibody
VEGFR2/KDR Monoclonal Antibody for FC
Host / Isotype
Mouse / IgG1
Reactivity
Human
Applications
FC
Conjugate
CoraLite® Plus 488 Fluorescent Dye
CloneNo.
1G2A8
验证数据展示
经过测试的应用
| Positive FC detected in | HUVEC cells |
For other applications, we recommend the unconjugated version of this antibody, 67407-1-Ig
推荐稀释比
| Application | Dilution |
|---|---|
| Flow Cytometry (FC) | FC : 0.80 ug per 10^6 cells in a 100 µl suspension |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
CL488-67407 targets VEGFR2/KDR in FC applications and shows reactivity with Human samples.
| Tested Applications | FC |
| Tested Reactivity | Human |
| Immunogen | VEGFR2/KDR fusion protein Ag24589 种属同源性预测 |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Full Name | kinase insert domain receptor (a type III receptor tyrosine kinase) |
| Synonyms | CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGFR, VEGFR 2, VEGFR2 |
| Calculated Molecular Weight | 1356 aa, 152 kDa |
| Observed Molecular Weight | 230 kDa |
| GenBank Accession Number | BC131822 |
| Gene Symbol | KDR |
| Gene ID (NCBI) | 3791 |
| Conjugate | CoraLite® Plus 488 Fluorescent Dye |
| Excitation/Emission Maxima Wavelengths | 493 nm / 522 nm |
| Form | Liquid |
| Purification Method | Protein G purification |
| UNIPROT ID | P35968 |
| Storage Buffer | PBS with 50% Glycerol, 0.05% Proclin300, 0.5% BSA, pH 7.3. |
| Storage Conditions | Store at -20°C. Avoid exposure to light. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
KDR, also named as VEGFR-2, FLK1 and CD309, is a receptor for VEGF or VEGFC. KDR which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. KDR functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.
实验方案
| Product Specific Protocols | |
|---|---|
| FC protocol for CL Plus 488 VEGFR2/KDR antibody CL488-67407 | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |