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Anti-Human VEGFR2/CD309 Rabbit Recombinant Antibody

VEGFR2/CD309 Recombinant Antibody for FC

Host / Isotype

Rabbit / IgG

Reactivity

Human

Applications

FC

Conjugate

Unconjugated

CloneNo.

230238B11

Cat No : 98009-1-RR

Print datasheet

Synonyms

CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGFR, VEGFR 2, VEGFR2

验证数据展示

  • FC experiment of HUVEC using 98009-1-RR

    FC experiment of HUVEC using 98009-1-RR

    1x10^6 HUVEC cells were surface stained with 0.25 ug Anti-Human VEGFR2/CD309 (98009-1-RR, Clone: 230238B11) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (red), or 0.25 ug Rabbit IgG control Rabbit PolyAb (30000-0-AP) and PE-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (blue). Cells were not fixed.

  • Affinity experiments of 98009-1-RR

    Affinity experiments of 98009-1-RR

    Surface Plasmon Resonance (SPR) kinetic assays of 98009-1-RR against Human VEGFR2/CD309 were performed. The affinity constant is 46.58 nM.

经过测试的应用

Positive FC detected inHUVEC cells

推荐稀释比

ApplicationDilution
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98009-1-RR targets VEGFR2/CD309 in FC applications and shows reactivity with Human samples.

Tested Applications FC
Tested Reactivity Human
Immunogen Recombinant protein 种属同源性预测
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Full Name kinase insert domain receptor (a type III receptor tyrosine kinase)
Synonyms CD309, Fetal liver kinase 1, FLK 1, FLK1, KDR, Kinase insert domain receptor, VEGFR, VEGFR 2, VEGFR2
Calculated Molecular Weight152kd
GenBank Accession NumberNM_002253
Gene Symbol KDR
Gene ID (NCBI) 3791
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purification
UNIPROT IDP35968-1
Storage Buffer PBS with 0.09% sodium azide.
Storage ConditionsStore at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

背景介绍

VEGFR2, also named as CD309, KDR and FLK1, is a receptor for VEGF or VEGFC. VEGFR2 which belongs to the protein kinase superfamily, has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. VEGFR2 functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. Mutations of this gene are implicated in infantile capillary hemangiomas.

实验方案

Product Specific Protocols
FC protocol for VEGFR2/CD309 antibody 98009-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols