验证数据展示
产品信息
15920-1-AP targets UBE2W in WB, IF, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IF |
| 经测试反应性 | human, mouse |
| 文献引用反应性 | human, mouse |
| 免疫原 | UBE2W fusion protein Ag8729 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | ubiquitin-conjugating enzyme E2W (putative) |
| 别名 | hUBC 16, UBE2W, Ubiquitin carrier protein W, Ubiquitin protein ligase W |
| 计算分子量 | 159 aa, 18 kDa |
| GenBank蛋白编号 | BC010900 |
| 基因名称 | UBE2W |
| Gene ID (NCBI) | 55284 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q96B02 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
UBE2W(Ubiquitin-conjugating enzyme E2 W) is also named as UBC16. The deduced 162-amino acid protein has an approximately 150-amino acid catalytic core, termed the E2 ubiquitin-conjugating enzyme (UBC) domain, which contains 2 nuclear localization signals at its C-terminal end. RT-PCR detected ubiquitous UBC16 expression, with highest expression in heart, brain, liver, and pancreas(PMID:16368532). Ube2w can form nuclear homodimers(PMID:21229326). It has 3 isoforms produced by alternative splicing.
发表文章
| Species | Application | Title |
|---|---|---|
Neurobiol Dis The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
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J Biol Chem Loss of the Ubiquitin-conjugating Enzyme UBE2W Results in Susceptibility to Early Postnatal Lethality and Defects in Skin, Immune, and Male Reproductive Systems.
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