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Terfenadine

Terfenadine ((±)-Terfenadine) 是一种hERG 开放通道抑制剂，IC50为 204 nM。它也是一种 H1 组胺受体拮抗剂，通过调节Ca2+稳态在黑素瘤细胞中起到有效的细胞凋亡诱导作用。 Terfenadine 诱导 ROS 依赖性细胞凋亡，同时激活Caspase-4，-2，-9。

CAS号

50679-08-8

分子式

C32H41NO2

主要靶点

5-HT Receptor|Histamine Receptor|AChR|Na+/Ca2+ Exchanger|Potassium Channel|Apoptosis|Caspase

仅限科研使用

Cat No : CM00542

Print datasheet

Synonyms

MDL 991|Terfenadine|特非那定|Potassium Channel|PotassiumChannel|Apoptosis|(±)-Terfenadine|5HT Receptor|5HTReceptor|Caspase|Ca2+Exchanger|Ca2+ Exchanger|hERG|HT|Histamine Receptor|HistamineReceptor|KcsA|inhibit|Inhibitor|MDL991|MDL-991|mAChR|Na+Exchanger|Na+/Ca2+ Exchanger|Na+ Exchanger

验证数据展示

  • CAS No.: 50679-08-8

    Terfenadine
    CAS#: 50679-08-8

产品信息

Terfenadine ((±)-Terfenadine) is a prodrug that is metabolized by intestinal CYP3A4 to the active form fexofenadine, a selective histamine H1-receptor antagonist with antihistaminic and non-sedative effects.

CAS号 50679-08-8
分子式 C32H41NO2
主要靶点 5-HT Receptor|Histamine Receptor|AChR|Na+/Ca2+ Exchanger|Potassium Channel|Apoptosis|Caspase
主要通路 离子通道|凋亡|神经科学|G 蛋白偶联受体|神经科学|蛋白酶体|凋亡|JAK/STAT 信号通路|蛋白酪氨酸激酶|血管生成|离子通道|神经科学|免疫与炎症|G 蛋白偶联受体
分子量 471.67
纯度 99.97%， 此纯度可做参考，具体纯度与批次有关系，可咨询客服
储存条件 Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
别名 MDL 991|Terfenadine|特非那定|Potassium Channel|PotassiumChannel|Apoptosis|(±)-Terfenadine|5HT Receptor|5HTReceptor|Caspase|Ca2+Exchanger|Ca2+ Exchanger|hERG|HT|Histamine Receptor|HistamineReceptor|KcsA|inhibit|Inhibitor|MDL991|MDL-991|mAChR|Na+Exchanger|Na+/Ca2+ Exchanger|Na+ Exchanger

靶点活性

ERG (human):204 nM

溶解度

DMSO:47.2 mg/mL (100.07 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.24 mM)

参考文献

1.Kishimoto W, et al. Res Commun Mol Pathol Pharmacol. 1997 Dec;98(3):273-92.

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