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验证数据展示

  • WB analysis of K-562 using 18243-1-AP (same clone as 18243-1-PBS)

    WB analysis of K-562 using 18243-1-AP (same clone as 18243-1-PBS)

    WB result of TXNIP antibody (18243-1-AP; 1:600; incubated at room temperature for 1.5 hours) with sh-Control and sh-TXNIP transfected K-562 cells. This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

  • WB analysis using 18243-1-AP (same clone as 18243-1-PBS)

    WB analysis using 18243-1-AP (same clone as 18243-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 18243-1-AP (TXNIP antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

  • IHC staining of human ovary tumor using 18243-1-AP (same clone as 18243-1-PBS)

    IHC staining of human ovary tumor using 18243-1-AP (same clone as 18243-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 18243-1-AP (TXNIP antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

  • IHC staining of human ovary tumor using 18243-1-AP (same clone as 18243-1-PBS)

    IHC staining of human ovary tumor using 18243-1-AP (same clone as 18243-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human ovary tumor tissue slide using 18243-1-AP (TXNIP antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 18243-1-AP (same clone as 18243-1-PBS)

    IHC staining of human kidney using 18243-1-AP (same clone as 18243-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 18243-1-AP (TXNIP Antibody) at dilution of 1:200 (under 10x lens). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

  • IP experiment of BxPC-3 using 18243-1-AP (same clone as 18243-1-PBS)

    IP experiment of BxPC-3 using 18243-1-AP (same clone as 18243-1-PBS)

    IP result of anti-TXNIP (IP:18243-1-AP, 4ug; Detection:18243-1-AP 1:1000) with BxPC-3 cells lysate 1320 ug. This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

  • IHC staining of human kidney using 18243-1-AP (same clone as 18243-1-PBS)

    IHC staining of human kidney using 18243-1-AP (same clone as 18243-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human kidney tissue slide using 18243-1-AP (TXNIP Antibody) at dilution of 1:200 (under 40x lens). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse colon using 18243-1-AP (same clone as 18243-1-PBS)

    IHC staining of mouse colon using 18243-1-AP (same clone as 18243-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 18243-1-AP (TXNIP antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

  • IHC staining of rat kidney using 18243-1-AP (same clone as 18243-1-PBS)

    IHC staining of rat kidney using 18243-1-AP (same clone as 18243-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat kidney tissue slide using 18243-1-AP (TXNIP antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

  • IP experiment of HL-60 using 18243-1-AP (same clone as 18243-1-PBS)

    IP experiment of HL-60 using 18243-1-AP (same clone as 18243-1-PBS)

    IP result of anti-TXNIP (IP:18243-1-AP, 4ug; Detection:18243-1-AP 1:1000) with HL-60 cells lysate 1480 ug. This data was developed using the same antibody clone with 18243-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

TXNIP Polyclonal antibody, PBS Only

TXNIP Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 18243-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, IP, Indirect ELISA

别名

Thioredoxin binding protein 2, thioredoxin interacting protein, Thioredoxin-binding protein 2, Thioredoxin-interacting protein, VDUP1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

18243-1-PBS targets TXNIP in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag13009

Product name: Recombinant human TXNIP protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-391 aa of BC093702

Sequence: MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 thioredoxin interacting protein
别名 Thioredoxin binding protein 2, thioredoxin interacting protein, Thioredoxin-binding protein 2, Thioredoxin-interacting protein, VDUP1
计算分子量 391 aa, 44 kDa
观测分子量 44-55 kDa
GenBank蛋白编号BC093702
基因名称 TXNIP
Gene ID (NCBI) 10628
RRIDAB_2876873
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9H3M7
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TXNIP, also known as VDUP-1 or TBP-2, belongs to alpha-arrestin protein family and is perhaps the only family member known to bind thioredoxin (TRX). TXNIP was induced by Vitamin D3, but not induced by another monocyte or macrophage differentiation inducer: phorbol 12-myristate 13-acetate (PMA). TXNIP bound catalytic active center of thioredoxin (TRX), which protected cells against oxidative stress. TXNIP was found to be a negative regulator of thioredoxin activity and inducer of the intracellular level of reactive oxygen species (ROS). TXNIP plays an important role in a wide variety of biological functions, such as the regulation of cell death, growth, differentiation, and energy metabolism.

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