验证数据展示
产品信息
13806-1-PBS targets TSSK2 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag4805 Product name: Recombinant human TSSK2 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-198 aa of BC037781 Sequence: MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYD 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | testis-specific serine kinase 2 |
| 别名 | Serine/threonine-protein kinase 22B, EC:2.7.11.1, DiGeorge syndrome protein G, DGS-G, DGSG |
| 计算分子量 | 358 aa, 41 kDa |
| 观测分子量 | 40 kDa |
| GenBank蛋白编号 | BC037781 |
| 基因名称 | TSSK2 |
| Gene ID (NCBI) | 23617 |
| RRID | AB_3741843 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q96PF2 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
TSSK2 (Testis-Specific Serine/Threonine Kinase 2) is a member of the TSSK family, predominantly expressed in the testis and involved in spermiogenesis and male fertility. It is localized in various regions of sperm, including the centrioles of post-meiotic spermatids, the tail, acrosomal regions, and the midpiece. TSSK2 plays a crucial role in sperm maturation by phosphorylating substrates such as TSKS and SPAG16L. Studies have shown that TSSK2 knockout mice exhibit infertility due to impaired spermatid elongation and sperm maturation. Additionally, TSSK2 is considered a promising target for reversible male contraception, with several potent inhibitors identified through high-throughput screening.
