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验证数据展示

  • WB analysis of THP-1 using 83438-6-RR (same clone as 83438-6-PBS)

    WB analysis of THP-1 using 83438-6-RR (same clone as 83438-6-PBS)

    PMA treated THP-1 cells were subjected to SDS PAGE followed by western blot with 83438-6-RR (TREM2 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83438-6-PBS in a different storage buffer formulation.

  • WB analysis of THP-1 using 83438-6-RR (same clone as 83438-6-PBS)

    WB analysis of THP-1 using 83438-6-RR (same clone as 83438-6-PBS)

    Non-treated and PMA treated THP-1 cellls were subjected to SDS PAGE followed by western blot with 83438-6-RR (TREM2 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 83438-6-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 83438-6-RR

    Affinity and Kinetic Characterization of 83438-6-RR

    Biolayer interferometry (BLl) kinetic assays of 83438-6-RR against Human TREM2 were performed. The affinity constant is 38.7 nM.

TREM2 Recombinant monoclonal antibody, PBS Only

TREM2 Uni-rAb® Recombinant Antibody for WB, ELISA
Cat No. 83438-6-PBS

产品说明书

CloneNo. 240384B7

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, ELISA

别名

240384B7, TREM 2, TREM-2, Trem2a, Trem2b

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy TREM2 Ready-To-Use IHC Kit. TREM2 primary antibody included.

产品信息

83438-6-PBS targets TREM2 in WB, ELISA applications and shows reactivity with human samples.

经测试应用 WB, ELISA Application Description
经测试反应性 human
免疫原

CatNo: Eg0747

Product name: Recombinant human TREM2 protein

Source: mammalian cells-derived, pHZ-KIsec-C-6*HIS

Tag: C-6*HIS

Domain: 19-174 aa of BC032362

Sequence: HNTTVFQGVAGQSLQVSCPYDSMKHWGRRKAWCRQLGEKGPCQRVVSTHNLWLLSFLRRWNGSTAITDDTLGGTLTITLRNLQPHDAGLYQCQSLHGSEADTLRKVLVEVLADPLDHRDAGDLWFPGESESFEDAHVEHSISRPSQGSHLPSCLSK

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 triggering receptor expressed on myeloid cells 2
别名 240384B7, TREM 2, TREM-2, Trem2a, Trem2b
计算分子量 222 aa, 25 kDa
观测分子量26-32 kDa
GenBank蛋白编号BC032362
基因名称 TREM2
Gene ID (NCBI) 54209
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ9NZC2
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TREM2 (triggering receptor expressed on myeloid cells 2) is a cell surface receptor belongs to TREM family that is expressed on osteoclast, dendritic cells, macrophages, nature killers, neutrophils and microglia (PMID: 19302484). TREM2 is localized predominantly in the Golgi complex, but also shuttles to and from the cell surface in endocytic and exocytic vesicles (PMID: 16675145). TREM2 associates with DAP12 to initiate the intracellular signalling cascade via an immunoreceptor tyrosine-based activation motif (ITAM) domain and tyrosine-kinases (PMID: 23977213).

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