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验证数据展示

  • WB analysis using 29904-1-AP (same clone as 29904-1-PBS)

    WB analysis using 29904-1-AP (same clone as 29904-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 29904-1-AP (TPH1 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 29904-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse cerebellum using 29904-1-AP (same clone as 29904-1-PBS)

    IHC staining of mouse cerebellum using 29904-1-AP (same clone as 29904-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse cerebellum tissue slide using 29904-1-AP (TPH1 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 29904-1-PBS in a different storage buffer formulation.

TPH1 Polyclonal antibody, PBS Only

TPH1 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 29904-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

EC:1.14.16.4, TPH, TPH 1, TPRH, TRPH

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

29904-1-PBS targets TPH1 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag31623

Product name: Recombinant human TPH1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 385-444 aa of BC106739

Sequence: KMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 tryptophan hydroxylase 1
别名 EC:1.14.16.4, TPH, TPH 1, TPRH, TRPH
计算分子量 466 aa, 53 kDa
观测分子量51 kDa
GenBank蛋白编号BC106739
基因名称 TPH1
Gene ID (NCBI) 7166
RRIDAB_3742319
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP17752
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Tryptophan hydroxylase 1 (TPH1) is the rate-limiting enzyme in the synthesis of serotonin (5-HT) from the amino acid tryptophan. It is primarily found in peripheral tissues such as the gut, pineal gland, and spleen. TPH1 plays a crucial role in regulating peripheral serotonin levels, which are involved in various physiological processes including gastrointestinal motility and cardiovascular function. Additionally, TPH1 has been implicated in the regulation of blood glucose levels and is associated with conditions such as fatty liver disease. (PMID: 32590025, PMID: 36331742, PMID: 37652099)

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