验证数据展示
产品信息
34301-1-PBS targets TOX in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
CatNo: Ag41257 Product name: Recombinant human TOX protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 50-235 aa of BC016665 Sequence: DYVPASQSYPGPSLESEDFNIPPITPPSLPDHSLVHLNEVESGYHSLCHPMNHNGLLPFHPQNMDLPEITVSNMLGQDGTLLSNSISVMPDIRNPEGTQYSSHPQMAAMRPRGQPADIRQQPGMMPHGQLTTINQSQLSAQLGLNMGGSNVPHNSPSPPGSKSATPSPSSSVHEDEGDDTSKINGG 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | thymocyte selection-associated high mobility group box |
| 别名 | KIAA0808, Thymocyte selection-associated high mobility group box protein TOX, TOX1 |
| 计算分子量 | 526 aa, 58 kDa |
| 观测分子量 | 57~70 kDa |
| GenBank蛋白编号 | BC016665 |
| 基因名称 | TOX |
| Gene ID (NCBI) | 9760 |
| RRID | AB_3743187 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity Purification |
| UNIPROT ID | O94900 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Thymocyte selection-associated high-mobility group box (TOX) is a DNA-binding factor that can regulate transcription by modifying local chromatin structure and modulating the formation of multi-protein complexes. TOX has multiple roles in the development of the adaptive immune system including development of CD4 T cells, NK cells and lymph node organogenesis (PMID: 35485425). Two bands detected at ~63 kDa and ~57kDa were presumed to be the unmodified form and the post-translationally form of TOX, respectively,(PMID: 32106280).
