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验证数据展示

  • WB analysis of rat skeletal muscle using 19729-1-AP (same clone as 19729-1-PBS)

    WB analysis of rat skeletal muscle using 19729-1-AP (same clone as 19729-1-PBS)

    rat skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 19729-1-AP (TNNT3 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 19729-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse skeletal muscle using 19729-1-AP (same clone as 19729-1-PBS)

    IHC staining of mouse skeletal muscle using 19729-1-AP (same clone as 19729-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 19729-1-AP (TNNT3 antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19729-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse skeletal muscle using 19729-1-AP (same clone as 19729-1-PBS)

    IHC staining of mouse skeletal muscle using 19729-1-AP (same clone as 19729-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 19729-1-AP (TNNT3 antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 19729-1-PBS in a different storage buffer formulation.

TNNT3 Polyclonal antibody, PBS Only

TNNT3 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 19729-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

Beta-TnTF, Fast skeletal muscle troponin T, Troponin T3 skeletal fast, Troponin T-FS

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

19729-1-PBS targets TNNT3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 troponin T type 3 (skeletal, fast)
别名 Beta-TnTF, Fast skeletal muscle troponin T, Troponin T3 skeletal fast, Troponin T-FS
计算分子量 32 kDa
观测分子量 35-40 kDa
GenBank蛋白编号NM_001042780
基因名称 TNNT3
Gene ID (NCBI) 7140
RRIDAB_2878601
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen Affinity purified
UNIPROT IDP45378
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The TNNT3 gene encodes the fast skeletal muscle isoform of troponin T, a key protein subunit of the troponin complex responsible for regulating skeletal muscle contraction in a calcium-dependent manner. This gene produces a protein that anchors the troponin complex to tropomyosin on the thin filaments of sarcomeres, playing a crucial role in the conformational changes that permit actin-myosin cross-bridge formation during muscle contraction. Tissue-specific expression is largely restricted to fast-twitch skeletal muscles, where alternative splicing generates multiple developmentally regulated isoforms. Clinically, dominant pathogenic mutations in TNNT3 are associated with distal arthrogryposis multiplex congenita type 2B (DA2B), also known as Sheldon-Hall syndrome, characterized by congenital joint contractures, while rare recessive variants have been linked to congenital myopathies featuring nemaline rods and fiber atrophy.

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