验证数据展示
产品信息
55323-1-PBS targets TNKS1BP1 in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | tankyrase 1 binding protein 1, 182kDa |
| 别名 | TAB182 |
| 计算分子量 | 182 kDa |
| 观测分子量 | 182 kDa |
| GenBank蛋白编号 | NM_033396 |
| 基因名称 | TNKS1BP1 |
| Gene ID (NCBI) | 85456 |
| RRID | AB_3743204 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q9C0C2 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
TNKS1BP1, also known as TAB182, is a member of the poly(ADP-ribose) polymerase (PARP) superfamily. It is an anchor polymerase 1 (Tankyrase1) binding protein with a molecular weight of 182 kDa and is widely distributed throughout the cell, including the cell membrane, cytoplasm, and nucleus. TNKS1BP1 functions in both telomere maintenance and DNA damage response. TNKS1BP1 can compete with TRF1 to bind to the multiple binding sites of tankyrase1, potentially interfering with the transport of tankyrase1 from cytoplasm to nucleus and its localization in telomeres, which affects the stability of telomeres (PMID: 28058814, PMID: 39019859, PMID: 39113018).
