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验证数据展示

  • WB analysis using 87840-1-RR (same clone as 87840-1-PBS)

    WB analysis using 87840-1-RR (same clone as 87840-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87840-1-RR (TNFRSF6B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87840-1-PBS in a different storage buffer formulation.

  • WB analysis of ACHN using 87840-1-RR (same clone as 87840-1-PBS)

    WB analysis of ACHN using 87840-1-RR (same clone as 87840-1-PBS)

    ACHN cells were subjected to SDS PAGE followed by western blot with 87840-1-RR (TNFRSF6B antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87840-1-PBS in a different storage buffer formulation.

  • Sandwich ELISA sample test of MP03265-1

    Sandwich ELISA sample test of MP03265-1

    SW 480 cells were cultured in DMEM supplemented with 10% fetal bovine serum, 2.5 mM L-glutamine, 100 U/mL penicillin, and 100 μg/mL streptomycin sulfate. An aliquot of the cell culture supernate was removed, assayed for human DcR3/TNFRSF6B, and measured 29.05 ng/mL.

  • Sandwich ELISA sample test of MP03265-1

    Sandwich ELISA sample test of MP03265-1

    Plasma of five individual healthy human donors was measured. The human DcR3/TNFRSF6B concentration of detected samples was determined to be 2.47 ng/mL with a range of 0.38 - 9.39 ng/mL.

  • Sandwich ELISA standard curve of MP03265-1

    Sandwich ELISA standard curve of MP03265-1

    Sandwich ELISA standard curve of MP03265-1, Human DcR3/TNFRSF6B Recombinant Matched Antibody Pair - PBS only. 87840-2-PBS was coated to a plate as the capture antibody and incubated with serial dilutions of standard Eg3110. 87840-1-PBS was HRP conjugated as the detection antibody. Range: 78.1-5000 pg/mL

  • Affinity of 87840-1-RR

    Affinity of 87840-1-RR

    Biolayer interferometry (BLI) kinetic assays of 87840-1-RR against Mouse TNFRSF6B were performed. The affinity constant is 0.131 nM.

TNFRSF6B Recombinant monoclonal antibody, PBS Only (Detector)

TNFRSF6B Uni-rAb® Recombinant Antibody for WB, Sandwich ELISA, Indirect ELISA
Cat No. 87840-1-PBS

产品说明书

CloneNo. 253457A6

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, Sandwich ELISA, Indirect ELISA

别名

DcR3, Decoy receptor 3, Decoy receptor for Fas ligand, M68, TR6

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

87840-1-PBS targets TNFRSF6B as part of a matched antibody pair:

MP03265-1: 87840-2-PBS capture and 87840-1-PBS detection (validated in Sandwich ELISA)

Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.

This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.

经测试应用 WB, Sandwich ELISA, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Eg3110

Product name: Recombinant human TNFRSF6B protein

Source: mammalian cells-derived, V37

Tag: C-rFc

Domain: 30-300 aa of NM_003823.3

Sequence: VAETPTYPWRDAETGERLVCAQCPPGTFVQRPCRRDSPTTCGPCPPRHYTQFWNYLERCRYCNVLCGEREEEARACHATHNRACRCRTGFFAHAGFCLEHASCPPGAGVIAPGTPSQNTQCQPCPPGTFSASSSSSEQCQPHRNCTALGLALNVPGSSSHDTLCTSCTGFPLSTRVPGAEECERAVIDFVAFQDISIKRLQRLLQALEAPEGWGPTPRAGRAALQLKLRRRLTELLGAQDGALLVRLLQALRVARMPGLERSVRERFLPVH

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 tumor necrosis factor receptor superfamily, member 6b, decoy
别名 DcR3, Decoy receptor 3, Decoy receptor for Fas ligand, M68, TR6
计算分子量33 kDa
观测分子量35 kDa
GenBank蛋白编号NM_003823.3
基因名称 TNFRSF6B
Gene ID (NCBI) 8771
RRIDAB_3745781
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDO95407
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The tumor necrosis factor receptor super-family member 6b (TNFRSF6B) is over-expressed in various human cancers. TNFRSF6B mRNA and protein expression in the tumor tissues negatively correlated with apoptosis. Cell proliferation was decreased, cell cycle was arrested in G1/S-phase, apoptosis was increased, and migration ability was inhibited by anti-TNFRSF6B McAb in vitro. Anti-TNFRSF6B McAb could be useful to suppress proliferation and induce apoptosis in HCC. Thus, TNFRSF6B might be a critical, targeted therapy strategy for HCC (PMID: 20591579).

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