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验证数据展示

  • WB analysis using 80165-1-RR (same clone as 80165-1-PBS)

    WB analysis using 80165-1-RR (same clone as 80165-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 80165-1-RR (TMEM173/STING antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 80165-1-PBS in a different storage buffer formulation.

  • IP experiment of HeLa using 80165-1-RR (same clone as 80165-1-PBS)

    IP experiment of HeLa using 80165-1-RR (same clone as 80165-1-PBS)

    IP result of anti-TMEM173/STING (IP: 80165-1-RR, 4ug; Detection: 80165-1-RR 1:8000) with HeLa cells lysate 1800 ug. This data was developed using the same antibody clone with 80165-1-PBS in a different storage buffer formulation.

  • IHC staining of human tonsillitis using 80165-1-RR (same clone as 80165-1-PBS)

    IHC staining of human tonsillitis using 80165-1-RR (same clone as 80165-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 80165-1-RR (TMEM173/STING antibody) at dilution of 1:2000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 80165-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with STING antibody included
  • IHC staining of human tonsillitis using 80165-1-RR (same clone as 80165-1-PBS)

    IHC staining of human tonsillitis using 80165-1-RR (same clone as 80165-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human tonsillitis tissue slide using 80165-1-RR (TMEM173/STING antibody) at dilution of 1:2000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 80165-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with STING antibody included
  • IF Staining of human tonsillitis using 80165-1-RR (same clone as 80165-1-PBS)

    IF Staining of human tonsillitis using 80165-1-RR (same clone as 80165-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed human tonsillitis tissue using TMEM173/STING antibody (80165-1-RR, Clone: 7K7 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 80165-1-PBS in a different storage buffer formulation.

  • IF Staining of THP-1 using 80165-1-RR (same clone as 80165-1-PBS)

    IF Staining of THP-1 using 80165-1-RR (same clone as 80165-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed THP-1 cells using TMEM173/STING antibody (80165-1-RR, Clone: 7K7 ) at dilution of 1:200 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 80165-1-PBS in a different storage buffer formulation.

  • IF Staining of mouse cerebellum using 80165-1-RR (same clone as 80165-1-PBS)

    IF Staining of mouse cerebellum using 80165-1-RR (same clone as 80165-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed frozen OCT-embedded mouse cerebellum tissue using TMEM173/STING antibody (80165-1-RR, Clone: 7K7 ) at dilution of 1:400 and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 80165-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 80165-1-RR

    Affinity and Kinetic Characterization of 80165-1-RR

    Biolayer interferometry (BLl) kinetic assays of 80165-1-RR against Human TMEM173/STING were performed. The affinity constant is 0.776 nM.

TMEM173/STING Recombinant antibody, PBS Only

TMEM173/STING Uni-rAbTM Recombinant Antibody for WB, IHC, IF/ICC, IF-P, IF-Fro, IP, Indirect ELISA
Cat No. 80165-1-PBS

产品说明书

CloneNo. 7K7

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, IF/ICC, IF-P, IF-Fro, IP, Indirect ELISA

别名

STING, 7K7, Endoplasmic reticulum interferon stimulator, ERIS, MITA

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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Planning an IHC experiment? We recommend our IHCeasy STING Ready-To-Use IHC Kit. STING primary antibody included.

产品信息

80165-1-PBS targets TMEM173/STING in WB, IHC, IF/ICC, IF-P, IF-Fro, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IF/ICC, IF-P, IF-Fro, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原 TMEM173/STING fusion protein Ag13921 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 transmembrane protein 173
别名 STING, 7K7, Endoplasmic reticulum interferon stimulator, ERIS, MITA
计算分子量 379 aa, 42 kDa
观测分子量37 kDa
GenBank蛋白编号BC047779
基因名称 STING
Gene ID (NCBI) 340061
RRIDAB_2918870
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purification
UNIPROT IDQ86WV6
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Stimulator of interferon genes (STING, also known as ERIS, MITA and MPYS, and encoded by TMEM173) is a transmembrane adaptor protein that facilitates innate immune signaling (PMID: 18724357). STING is widely expressed in various cell types such as endothelial cells, epithelial cells, T cells, macrophages, and dendritic cells (PMID: 26603901). It is predominantly located in the endoplasmic reticulum (ER). STING functions as a sensor of cytosolic DNA and promotes the production of type I interferons and pro-inflammatory cytokines.