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验证数据展示

  • WB analysis using 86440-1-RR (same clone as 86440-1-PBS)

    WB analysis using 86440-1-RR (same clone as 86440-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 86440-1-RR (TMCO1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 86440-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 86440-1-RR (same clone as 86440-1-PBS)

    IHC staining of human liver cancer using 86440-1-RR (same clone as 86440-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 86440-1-RR (TMCO1 antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86440-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver cancer using 86440-1-RR (same clone as 86440-1-PBS)

    IHC staining of human liver cancer using 86440-1-RR (same clone as 86440-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver cancer tissue slide using 86440-1-RR (TMCO1 antibody) at dilution of 1:1000 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 86440-1-PBS in a different storage buffer formulation.

  • Affinity of 86440-1-RR

    Affinity of 86440-1-RR

    Biolayer interferometry (BLl) kinetic assays of 86440-1-RR against Human TMCO1 were performed. The affinity constant is 0.73 nM.

TMCO1 Recombinant monoclonal antibody, PBS Only

TMCO1 Uni-rAb® Recombinant Antibody for WB, IHC, Indirect ELISA
Cat No. 86440-1-PBS

产品说明书

CloneNo. 251064F7

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

WB, IHC, Indirect ELISA

别名

HP10122, PCIA3, PNAS 136, RP11 466F5.7, TMCC4

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

86440-1-PBS targets TMCO1 in WB, IHC, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag26278

Product name: Recombinant human TMCO1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 111-188 aa of NM_019026

Sequence: MGRVVAKLPFTPLSYIQGLSHRNLLGDDTTDCSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAGGFLGPPPPSGKFS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 transmembrane and coiled-coil domains 1
别名 HP10122, PCIA3, PNAS 136, RP11 466F5.7, TMCC4
计算分子量 21 kDa
观测分子量 20 kDa
GenBank蛋白编号NM_019026
基因名称 TMCO1
Gene ID (NCBI) 54499
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ9UM00
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TMCO1, also known as TMCC4, PNAS-10, and PNAS-136, is a 188 amino acid protein, which is widely expressed in adult and fetal tissues, with higher levels in thymus, prostate, testis and small intestine and lower levels in brain, placenta, lung and kidney (PubMed:10393320, PubMed:20018682). TMCO1 as a Calcium-selective channel is required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis (PubMed:27212239). In response to endoplasmic reticulum overloading, TMCO1, assembles into a homotetramer, forming a functional calcium-selective channel, regulating the calcium content in endoplasmic reticulum store (PubMed:27212239).

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