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验证数据展示

  • WB analysis using 27671-1-AP (same clone as 27671-1-PBS)

    WB analysis using 27671-1-AP (same clone as 27671-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27671-1-AP (TM6SF2 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27671-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 27671-1-AP (same clone as 27671-1-PBS)

    IHC staining of human liver using 27671-1-AP (same clone as 27671-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 27671-1-AP (TM6SF2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27671-1-PBS in a different storage buffer formulation.

  • IHC staining of human liver using 27671-1-AP (same clone as 27671-1-PBS)

    IHC staining of human liver using 27671-1-AP (same clone as 27671-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human liver tissue slide using 27671-1-AP (TM6SF2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27671-1-PBS in a different storage buffer formulation.

TM6SF2 Polyclonal antibody, PBS Only

TM6SF2 Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 27671-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, Indirect ELISA

别名

KIAA1926, Transmembrane 6 superfamily member 2

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

27671-1-PBS targets TM6SF2 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag26527

Product name: Recombinant human TM6SF2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 289-377 aa of NM_001001524

Sequence: MFPGCSWLPDWALVFAGGIGQAQFSHMGASMHLRTPFTYRVPEDTWGCFFVCNLLYALGPHLLAYRCLQWPAFFHQPPPSDPLALHKKQH

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 transmembrane 6 superfamily member 2
别名 KIAA1926, Transmembrane 6 superfamily member 2
计算分子量 43 kDa
观测分子量 43 kDa
GenBank蛋白编号NM_001001524
基因名称 TM6SF2
Gene ID (NCBI) 533
RRIDAB_3085983
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9BZW4
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TM6SF2 is mainly expressed in the liver, intestine, kidney, and in other tissues at low levels. In terms of subcellular localization, TM6SF2 is localized in the endoplasmic reticulum (ER), the ER-Golgi intermediate compartment, and Golgi of liver cells and enterocytes. The loss of TM6SF2 promotes the release of free fatty acids from IECs, leading to intestinal barrier dysfunction, gut microbiota dysbiosis and metabolite alterations (PMID: 29232562, 27013658). TM6SF2 encodes a protein predicted to have 7-10 transmembrane domains, containing 351 amino acids (39.5-kDa) with an estimated isoelectric point (pI) of 8.29 (PMID: 39779889).

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