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验证数据展示

  • WB analysis of HEK-293 using 66083-1-Ig (same clone as 66083-1-PBS)

    WB analysis of HEK-293 using 66083-1-Ig (same clone as 66083-1-PBS)

    HEK-293 cells were subjected to SDS PAGE followed by western blot with 66083-1-Ig (TLE3 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 66083-1-PBS in a different storage buffer formulation.

  • IHC staining of human breast cancer using 66083-1-Ig (same clone as 66083-1-PBS)

    IHC staining of human breast cancer using 66083-1-Ig (same clone as 66083-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human breast cancer slide using 66083-1-Ig (TLE3 Antibody) at dilution of 1:50. This data was developed using the same antibody clone with 66083-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with TLE3 antibody included
  • IP experiment of HEK-293 using 66083-1-Ig (same clone as 66083-1-PBS)

    IP experiment of HEK-293 using 66083-1-Ig (same clone as 66083-1-PBS)

    IP result of anti-TLE3 (IP:66083-1-Ig, 5ug; Detection:66083-1-Ig 1:500) with HEK-293 cells lysate 1480ug. This data was developed using the same antibody clone with 66083-1-PBS in a different storage buffer formulation.

TLE3 Monoclonal antibody, PBS Only

TLE3 Monoclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 66083-1-PBS

产品说明书

CloneNo. 1D11A8

宿主/亚型

Mouse / IgG1

种属反应性

human

应用

WB, IHC, IP, Indirect ELISA

别名

1D11A8, Enhancer of split groucho-like protein 3, ESG, ESG3, GRG 3

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy TLE3 Ready-To-Use IHC Kit. TLE3 primary antibody included.

产品信息

66083-1-PBS targets TLE3 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag17906

Product name: Recombinant human TLE3 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-350 aa of BC015729

Sequence: MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDPI

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
别名 1D11A8, Enhancer of split groucho-like protein 3, ESG, ESG3, GRG 3
计算分子量 772 aa, 83 kDa
观测分子量 90 kDa
GenBank蛋白编号BC015729
基因名称 TLE3
Gene ID (NCBI) 7090
RRIDAB_11182267
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDQ04726
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TLE3, also named as KIAA1547 and ESG3, belongs to the WD repeat Groucho/TLE family. It is a transcriptional corepressor that binds to a number of transcription factors. It inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. TLE3 is a member of the transducin-like enhancer of split (TLE) family of proteins that have been implicated in the tumorgenesis and classification of sarcomas. It is a candidate biomarker of response to taxane therapy.(PMID:19309506 )

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