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验证数据展示

  • WB analysis of Jurkat using 87332-1-RR (same clone as 87332-1-PBS)

    WB analysis of Jurkat using 87332-1-RR (same clone as 87332-1-PBS)

    Jurkat cells were subjected to SDS PAGE followed by western blot with 87332-1-RR (TLE1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87332-1-PBS in a different storage buffer formulation.

  • WB analysis using 87332-1-RR (same clone as 87332-1-PBS)

    WB analysis using 87332-1-RR (same clone as 87332-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 87332-1-RR (TLE1 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 87332-1-PBS in a different storage buffer formulation.

  • Affinity of 87332-1-RR

    Affinity of 87332-1-RR

    Biolayer interferometry (BLl) kinetic assays of 87332-1-RR against Human TLE1 were performed. The affinity constant is 1.29 nM.

TLE1 Recombinant monoclonal antibody, PBS Only

TLE1 Uni-rAb® Recombinant Antibody for WB, Indirect ELISA
Cat No. 87332-1-PBS

产品说明书

CloneNo. 252574H3

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, Indirect ELISA

别名

Enhancer of split groucho-like protein 1, GRG1, Transducin-like enhancer protein 1

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

87332-1-PBS targets TLE1 in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag17299

Product name: Recombinant human TLE1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 281-377 aa of BC010100

Sequence: KDASSSPASTASSASSTSLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRTPLAVPGPYPAPFGMVPH

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
别名 Enhancer of split groucho-like protein 1, GRG1, Transducin-like enhancer protein 1
计算分子量 770 aa, 83 kDa
观测分子量 80-95 kDa
GenBank蛋白编号BC010100
基因名称 TLE1
Gene ID (NCBI) 7088
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ04724
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

TLE1 (Transducin-like enhancer protein 1) is a transcriptional corepressor and binds to a number of transcription factors. It can inhibit NF-kappa-B-regulated gene expression and the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (PMID: 10660609). TLE1 is highly expressed in postnatal brain (PMID: 29758293; 27852056).

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