验证数据展示
| Neutralization |
发表文章中的应用
| WB | See 1 publications below |
| IHC | See 2 publications below |
产品信息
69012-1-Ig targets NeutraKine® TGF beta 1 in WB, IHC, Neutralization, ELISA applications and shows reactivity with Human samples.
| 经测试应用 | IHC, ELISA, Neutralization Application Description |
| 文献引用应用 | WB, IHC, Neutralization |
| 经测试反应性 | Human |
| 文献引用反应性 | human, mouse |
| 免疫原 | human Humankine TGF beta 1 protein HZ-1011 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | transforming growth factor, beta 1 |
| 别名 | TGFB1, TGFB1,TGF beta 1,TGFbeta,TGF-beta 1, TGF-beta1, TGFB, tgf beta1 |
| 计算分子量 | 44 kDa |
| 基因名称 | TGFB1 |
| Gene ID (NCBI) | 7040 |
| RRID | AB_2882930 |
| 偶联类型 | Unconjugated |
| 形式 | Lyophilized Powder |
| 纯化方式 | Protein G purification |
| 储存缓冲液 | Sterile PBS , pH 7.4 |
| 内毒素 | <0.1 EU/μg |
| 复溶 | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
| 稳定性与储存 | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
背景介绍
TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease (CED) which known as progressive diaphyseal dysplasia 1 (DPD1).
This antibody can be used to neutralize the bioactivity of TGF beta 1.
实验方案
| Product Specific Protocols | |
|---|---|
| IHC protocol for NeutraKine® TGF beta 1 antibody 69012-1-Ig | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Bioengineered Emodin suppresses hepatocellular carcinoma growth by regulating macrophage polarization via microRNA-26a/transforming growth factor beta 1/protein kinase B. | ||
Cell Death Discov A positive feedback loop: RAD18-YAP-TGF-β between triple-negative breast cancer and macrophages regulates cancer stemness and progression. | ||
Nature Co-transplantation of autologous Treg cells in a cell therapy for Parkinson's disease | ||
Stem Cell Res Ther Blockade of TGF-β signalling alleviates human adipose stem cell senescence induced by native ECM in obesity visceral white adipose tissue | ||
Am J Pathol Latent-transforming growth factor β-binding protein 1/Transforming growth factor β1 complex drives antitumoral effects upon ERK5 targeting in melanoma | ||
Sci Rep Treg-derived TGF-β1 dampens cGAS-STING signaling to downregulate the expression of class I MHC complex in multiple myeloma |