验证数据展示
产品信息
27586-1-AP targets TERT in WB, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB, IF |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag26270 Product name: Recombinant human TERT protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 219-320 aa of NM_001193376 Sequence: MPGARRRGGSASRSLPLPKRPRRGAAPEPERTPVGQGSWAHPGRTRGPSDRGFCVVSPARPAEEATSLEGALSGTRHSHPSVGRQHHAGPPSTSRPPRPWDTP 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | telomerase reverse transcriptase |
| 别名 | EC:2.7.7.49, EST2, hEST2, hTERT, TCS1 |
| 计算分子量 | 127 kDa |
| 观测分子量 | ~100 kDa |
| GenBank蛋白编号 | NM_001193376 |
| 基因名称 | TERT |
| Gene ID (NCBI) | 7015 |
| RRID | AB_3085971 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | O14746 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Telomerase reverse transcriptase (TERT) is a catalytic subunit of telomerase. TERT plays a key role in cancer formation, ensuring chromosomal stability by maintaining telomere length, and allowing cells to avert senescence. It constitutes a limiting factor for formation of the telomerase complex in cancer cells. TERT is one of two major components of the larger telomerase complex, which extends telomeres by adding specific short repetitive DNA sequences. Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. The calculated MW of TERT is 127 kDa, 27586-1-AP can detect a band around 100 kDa.
发表文章
| Species | Application | Title |
|---|---|---|
Chem Biol Interact Telomerase reverse transcriptase protects against diabetic kidney disease by promoting AMPK/PGC-1a-regulated mitochondrial energy homeostasis | ||
Toxicology Chronic low-level exposure to Pb, Hg, and Cd mixture triggers brain premature aging in rat | ||
Nat Commun Time-resolved multiomics profiling reveals chromatin O-GlcNAc modification promotes senescence-associated transcriptional program. | ||
Int J Biol Macromol NRF2-TERT-ACSL4 pathway inhibits ferroptosis and regulates cytoskeletal dynamics to mitigate ovarian aging.
| ||
FASEB J CAF-Secreted Exosomes Deliver BMP4 to Confer Radiotherapy Resistance in Cervical Cancer Through a Novel Mechanism Linking Nrf2 Activation to Cuproptosis Inhibition. | ||
PLoS Pathog Genome-wide CRISPR screen reveals PEX11B as a host restriction factor against ORFV through membrane fluidity regulation. |
