验证数据展示
发表文章中的应用
| IF | See 1 publications below |
产品信息
27841-1-AP targets TDP-43 in IF, ELISA applications and shows reactivity with Human, Mouse samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | IF |
| 经测试反应性 | Human, Mouse |
| 文献引用反应性 | human |
| 免疫原 |
CatNo: Ag26155 Product name: Recombinant human TDP-43 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 184-414 aa of BC001487 Sequence: QDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | TAR DNA binding protein |
| 别名 | ALS10, TAR DNA binding protein, TAR DNA binding protein 43, TARDBP, TDP 43, TDP43 |
| 计算分子量 | 43 kDa |
| 观测分子量 | 37-40 kDa |
| GenBank蛋白编号 | BC001487 |
| 基因名称 | TDP-43 |
| Gene ID (NCBI) | 23435 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q13148 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
TDP-43 is a DNA and RNA-binding protein which regulates transcription and splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. TDP-43 can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat and stabilize the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. Besides, it may also be involved in microRNA biogenesis, apoptosis and cell division. 27841-1-AP is a rabbit polyclonal antibody recognises the 37-40 kDa protein because of the cleaved fragments and posttranslationally modification.
发表文章
| Species | Application | Title |
|---|---|---|
Free Radic Biol Med Edaravone mitigates TDP-43 mislocalization in human amyotrophic lateral sclerosis neurons with potential implication of the SIRT1-XBP1 pathway | ||
bioRxiv Differential Cellular Mechanisms Underlie Language and Executive Decline in Amyotrophic Lateral Sclerosis |
