验证数据展示
产品信息
88217-1-PBS targets TAF6L in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag8180 Product name: Recombinant human TAF6L protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-351 aa of BC008785 Sequence: MSEREERRFVEIPRESVRLMAESTGLELSDEVAALLAEDVCYRLREATQNSSQFMKHTKRRKLTVEDFNRALRWSSVEAVCGYGSQEALPMRPAREGELYFPEDREVNLVELALATNIPKGCAETAVRVHVSYLDGKGNLAPQGSVPSAVSSLTDDLLKYYHQVTRAVLGDDPQLMKVALQDLQTNSKIGALLPYFVYVVSGVKSVSHDLEQLHRLLQVARSLFRNPHLCLGPYVRCLVGSVLYCVLEPLAASINPLNDHWTLRDGAALLLSHIFWTHGDLVSGLYQHILLSLQKILADPVRPLCCHYGAVVGLHALGWKAVERVLYPHLSTYWTNLQAVLDDYSVSNAQV 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa |
| 别名 | PAF65 alpha, PAF65A, PAF65-alpha, PCAF-associated factor 65-alpha, TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L |
| 计算分子量 | 622 aa, 68 kDa |
| 观测分子量 | 68 kDa |
| GenBank蛋白编号 | BC008785 |
| 基因名称 | TAF6L |
| Gene ID (NCBI) | 10629 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q9Y6J9 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
TAF6L (TBP-associated factor 6-like protein, also known as PAF65α) is a core component of the PCAF histone acetyltransferase complex and the STAGA transcriptional coactivation complex. This protein contains a characteristic histone folding domain (HFD) and is primarily located in the cell nucleus. As an epigenetic regulator, TAF6L works synergistically with TAF5L to promote the transcriptional elongation of RNA polymerase II by mediating H3K9ac deposition and MYC recruitment, thereby regulating embryonic stem cell pluripotency and somatic cell reprogramming.
