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验证数据展示

  • WB analysis using 27524-1-AP (same clone as 27524-1-PBS)

    WB analysis using 27524-1-AP (same clone as 27524-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27524-1-AP (Supervillin antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27524-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse heart using 27524-1-AP (same clone as 27524-1-PBS)

    IHC staining of mouse heart using 27524-1-AP (same clone as 27524-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 27524-1-AP (Supervillin antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27524-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse skeletal muscle using 27524-1-AP (same clone as 27524-1-PBS)

    IHC staining of mouse skeletal muscle using 27524-1-AP (same clone as 27524-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 27524-1-AP (Supervillin antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27524-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse skeletal muscle using 27524-1-AP (same clone as 27524-1-PBS)

    IHC staining of mouse skeletal muscle using 27524-1-AP (same clone as 27524-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 27524-1-AP (Supervillin antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27524-1-PBS in a different storage buffer formulation.

Supervillin Polyclonal antibody, PBS Only

Supervillin Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 27524-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

SVIL

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

27524-1-PBS targets Supervillin in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag26196

Product name: Recombinant human Supervillin protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1679-1787 aa of NM_003174

Sequence: MFLDWTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEGHDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKF

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 supervillin
别名 SVIL
计算分子量 248 kDa
观测分子量 205 kDa
GenBank蛋白编号NM_003174
基因名称 SVIL
Gene ID (NCBI) 6840
RRIDAB_3669607
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO95425
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Supervillin (SVIL) belongs to the villin/gelsolin superfamily of actin-binding proteins involved in many cellular processes. A non-muscle-specific form of Supervillin activates androgen receptor activity. Supervillin another isoform, called Archvillin, is expressed in skeletal and cardiac muscle tissue where it plays a role in both muscle fiber structure and signaling. Mutations in Supervillin are associated with myofibrillar Myopathy10 (MFM10), which causes myopathy with myofibrillar disorganization and autophagic vacuoles(PMID: 9867483, 32779703).

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