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验证数据展示

  • WB analysis using 27370-1-AP (same clone as 27370-1-PBS)

    WB analysis using 27370-1-AP (same clone as 27370-1-PBS)

    RT-4 cells were subjected to SDS PAGE followed by western blot with 27370-1-AP (SPPL2B antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27370-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse brain using 27370-1-AP (same clone as 27370-1-PBS)

    IHC staining of mouse brain using 27370-1-AP (same clone as 27370-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 27370-1-AP (SPPL2B antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27370-1-PBS in a different storage buffer formulation.

SPPL2B Polyclonal antibody, PBS Only

SPPL2B Polyclonal Antibody for WB, IHC, Indirect ELISA
Cat No. 27370-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, Indirect ELISA

别名

IMP 4, IMP4, Intramembrane protease 4, KIAA1532, Presenilin like protein 1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

27370-1-PBS targets SPPL2B in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag25551

Product name: Recombinant human SPPL2B protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 40-113 aa of BC028391

Sequence: EGKDYCILYNPQWAHLPHDLSKASFLQLRNWTASLLCSAADLPARGFSNQIPLVARGNCTFYEKVRLAQGSGAR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 signal peptide peptidase-like 2B
别名 IMP 4, IMP4, Intramembrane protease 4, KIAA1532, Presenilin like protein 1
计算分子量 65 kDa
观测分子量56 kDa
GenBank蛋白编号BC028391
基因名称 SPPL2B
Gene ID (NCBI) 56928
RRIDAB_3742228
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ8TCT7
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SPPL2B (Signal Peptide Peptidase-Like 2B) is a multi-pass transmembrane aspartyl protease belonging to the GXGD family of intramembrane proteases. SPPL2B contains two conserved catalytic aspartate motifs localized within its membrane-spanning regions, similar to presenilins and γ-secretase. It localizes primarily to endosomes, lysosomes, and the plasma membrane, distinguishing it from ER-resident SPP and SPPL3. (PMID: 32052089, PMID: 19429495)

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