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验证数据展示

  • WB analysis using 24643-1-AP (same clone as 24643-1-PBS)

    WB analysis using 24643-1-AP (same clone as 24643-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 24643-1-AP (SORBS2 antibody) at dilution of 1:3000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 24643-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse heart using 24643-1-AP (same clone as 24643-1-PBS)

    IP experiment of mouse heart using 24643-1-AP (same clone as 24643-1-PBS)

    IP result of anti-SORBS2 (IP:24643-1-AP, 4ug; Detection:24643-1-AP 1:500) with mouse heart tissue lysate 4000ug. This data was developed using the same antibody clone with 24643-1-PBS in a different storage buffer formulation.

  • IHC staining of human pancreas cancer using 24643-1-AP (same clone as 24643-1-PBS)

    IHC staining of human pancreas cancer using 24643-1-AP (same clone as 24643-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human pancreas cancer tissue slide using 24643-1-AP (SORBS2 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24643-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SORBS2 antibody included
  • IHC staining of mouse heart using 24643-1-AP (same clone as 24643-1-PBS)

    IHC staining of mouse heart using 24643-1-AP (same clone as 24643-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse heart tissue slide using 24643-1-AP (SORBS2 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 24643-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with SORBS2 antibody included
  • IF Staining of U2OS using 24643-1-AP (same clone as 24643-1-PBS)

    IF Staining of U2OS using 24643-1-AP (same clone as 24643-1-PBS)

    Immunofluorescent analysis of (4% PFA) fixed U2OS cells using SORBS2 antibody (24643-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 24643-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

SORBS2 Polyclonal antibody, PBS Only

SORBS2 Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 24643-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, canine

应用

WB, IHC, IF/ICC, IP, Indirect ELISA

别名

Arg/Abl-interacting protein 2, Arg-binding protein 2, ArgBP2, Sorbin and SH3 domain-containing protein 2

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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Planning an IHC experiment? We recommend our IHCeasy SORBS2 Ready-To-Use IHC Kit. SORBS2 primary antibody included.

产品信息

24643-1-PBS targets SORBS2 in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human, mouse, canine samples.

经测试应用 WB, IHC, IF/ICC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, canine
免疫原

CatNo: Ag20041

Product name: Recombinant human SORBS2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-198 aa of BC011883

Sequence: MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDR

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 sorbin and SH3 domain containing 2
别名 Arg/Abl-interacting protein 2, Arg-binding protein 2, ArgBP2, Sorbin and SH3 domain-containing protein 2
计算分子量 1100 aa, 124 kDa
观测分子量 70-75 kDa
GenBank蛋白编号BC011883
基因名称 SORBS2
Gene ID (NCBI) 8470
RRIDAB_2879652
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO94875
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SORBS2, also known as ARGBP2, has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. SORBS2 is widely expressed in human tissues and extremely abundant in the heart. In epithelial cells SORBS2 is located in stress fibers and the nucleus; In cardiac muscle cells. SORBS2 is located in the Z-disks of sarcomeres. The subcellular localization suggests that SORBS2 functions as an adapter protein to assemble signaling complexes in stress fibers, and may influence the contractile or elastic properties of cardiac sarcomeres(PMID: 9211900). Alternate splicing results in multiple transcript variants( PMID: 28961272).

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