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验证数据展示

  • WB analysis of 3T3-L1 using 13854-1-AP (same clone as 13854-1-PBS)

    WB analysis of 3T3-L1 using 13854-1-AP (same clone as 13854-1-PBS)

    3T3-L1 cells were subjected to SDS PAGE followed by western blot with 13854-1-AP (SORBS1 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 13854-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse liver using 13854-1-AP (same clone as 13854-1-PBS)

    IP experiment of mouse liver using 13854-1-AP (same clone as 13854-1-PBS)

    IP result of anti-SORBS1 (IP:13854-1-AP, 4ug; Detection:13854-1-AP 1:800) with mouse liver tissue lysate 4800ug. This data was developed using the same antibody clone with 13854-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 13854-1-AP (same clone as 13854-1-PBS)

    IHC staining of human colon using 13854-1-AP (same clone as 13854-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human normal colon slide using 13854-1-AP (SORBS1 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13854-1-PBS in a different storage buffer formulation.

  • IHC staining of human stomach using 13854-1-AP (same clone as 13854-1-PBS)

    IHC staining of human stomach using 13854-1-AP (same clone as 13854-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 13854-1-AP (SORBS1 antibody) at dilution of 1:200 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 13854-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

SORBS1 Polyclonal antibody, PBS Only

SORBS1 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 13854-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IP, Indirect ELISA

别名

CAP, c-Cbl-associated protein, SH3D5, SORB1, Sorbin and SH3 domain-containing protein 1

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

13854-1-PBS targets SORBS1 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag4828

Product name: Recombinant human SORBS1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-300 aa of BC042612

Sequence: MSSECDGGSKAVMNGLAPGSNGQDKDMDPTKICTGKGAVTLRASSSYRETPSSSPASPQETRQHESKPDEWRLSSSADANGNAQPSSLAAKGYRSVHPNLPSDKSQDATSSSAAQPEVIVVPLYLVNTDRGQEGTARPPTPLGPLGCVPTIPATASAASPLTFPTLDDFIPPHLQRWPHHSQPARASGSFAPISQTPPSFSPPPPLVPPAPEDLRRVSEPDLTGAVSSTDSSPLLNEVSSSLIGTDSQAFPSVSKPSSAYPSTTIVNPTIVLLQHNREQQKRLSSLSDPVSERRVGEQDS

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 sorbin and SH3 domain containing 1
别名 CAP, c-Cbl-associated protein, SH3D5, SORB1, Sorbin and SH3 domain-containing protein 1
计算分子量 1292 aa, 142 kDa
观测分子量 70-75 kDa
GenBank蛋白编号BC042612
基因名称 SORBS1
Gene ID (NCBI) 10580
RRIDAB_11232224
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9BX66
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

The sorbin homology (SoHo) family of adapter and scaffold proteins consists of three proteins: CAP, also known as Sorbin and SH3 domain containing 1 (Sorbs1), ArgBP2, also known as Sorbs2, and Vinexin, also known as Sorbs3. All Sorbs proteins are highly expressed in heart tissue, skeletal muscle, adipose tissue, and cells of the immune system, functioning as SH3-domain-mediated adaptors of scaffolding molecules(PMID: 32738595). SORBS1 can bind to signaling molecules (e.g., c-Cbl, c-Abl, and insulin reporter) to regulate glucose transport, transcription activity, and insulin signaling(PMID: 27791200).

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