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验证数据展示

  • WB analysis using 27343-1-AP (same clone as 27343-1-PBS)

    WB analysis using 27343-1-AP (same clone as 27343-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 27343-1-AP (SOCS6 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

  • IP experiment of NIH/3T3 using 27343-1-AP (same clone as 27343-1-PBS)

    IP experiment of NIH/3T3 using 27343-1-AP (same clone as 27343-1-PBS)

    IP result of anti-SOCS6 (IP:27343-1-AP, 4ug; Detection:27343-1-AP 1:1500) with NIH/3T3 cells lysate 1200 ug. This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 27343-1-AP (same clone as 27343-1-PBS)

    IHC staining of human colon using 27343-1-AP (same clone as 27343-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 27343-1-AP (SOCS6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

  • IHC staining of human colon using 27343-1-AP (same clone as 27343-1-PBS)

    IHC staining of human colon using 27343-1-AP (same clone as 27343-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human colon tissue slide using 27343-1-AP (SOCS6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

  • IP experiment of human placenta using 27343-1-AP (same clone as 27343-1-PBS)

    IP experiment of human placenta using 27343-1-AP (same clone as 27343-1-PBS)

    IP result of anti-SOCS6 (IP:27343-1-AP, 4ug; Detection:27343-1-AP 1:1500) with human placenta tissue lysate 960 ug. This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse colon using 27343-1-AP (same clone as 27343-1-PBS)

    IHC staining of mouse colon using 27343-1-AP (same clone as 27343-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 27343-1-AP (SOCS6 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

  • IHC staining of mouse colon using 27343-1-AP (same clone as 27343-1-PBS)

    IHC staining of mouse colon using 27343-1-AP (same clone as 27343-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 27343-1-AP (SOCS6 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 27343-1-PBS in a different storage buffer formulation.

SOCS6 Polyclonal antibody, PBS Only

SOCS6 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 27343-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse

应用

WB, IHC, IP, Indirect ELISA

别名

CIS 4, CIS4, CIS-4, Cytokine-inducible SH2 protein 4, HSPC060

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

27343-1-PBS targets SOCS6 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse
免疫原

CatNo: Ag25594

Product name: Recombinant human SOCS6 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 132-385 aa of BC020082

Sequence: YSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWY

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 suppressor of cytokine signaling 6
别名 CIS 4, CIS4, CIS-4, Cytokine-inducible SH2 protein 4, HSPC060
计算分子量 60 kDa
观测分子量 60-75 kDa
GenBank蛋白编号BC020082
基因名称 SOCS6
Gene ID (NCBI) 9306
RRIDAB_3669595
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO14544
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SOCS6 (Suppressor of cytokine signaling 6) is also named as CIS4 and SOCS4. SOCS6 is one of eight members of the SOCS family of proteins. SOCS6 is involved in negative regulation of receptor signaling by increasing degradation mediated by ubiquitination of receptors or substrate proteins and induces apoptosis by targeting mitochondrial proteins (PMID: 25172101). SOCS6 is widely expressed in many tissues and is found to be downregulated in many cancers including colorectal cancer, gastric cancer, lung cancer, ovarian cancer, stomach cancer, thyroid cancer, hepatocellular carcinoma, and pancreatic cancer (PMID: 25172101). In addition to its molecular weight of 60 kDa, SOCS6 has a 70 kDa isoform (PMID: 34169835, PMID: 22125600).

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