验证数据展示
产品信息
66851-2-PBS targets SMO in IF/ICC, Indirect ELISA applications and shows reactivity with Human, Canine samples.
| 经测试应用 | IF/ICC, Indirect ELISA Application Description |
| 经测试反应性 | Human, Canine |
| 免疫原 |
CatNo: Ag25861 Product name: Recombinant human SMO protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 28-233 aa of BC009989 Sequence: RGAASSGNATGPGPRSAGGSARRSAAVTGPPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSY 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG1 |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | smoothened homolog (Drosophila) |
| 别名 | Gx, Protein Gx, SMO, SMOH, Smoothened homolog |
| 计算分子量 | 787 aa, 86 kDa |
| GenBank蛋白编号 | BC009989 |
| 基因名称 | SMO |
| Gene ID (NCBI) | 6608 |
| RRID | AB_3085033 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein G purification |
| UNIPROT ID | Q99835 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Smoothened (SMO) is a G protein-coupled receptor that is a component of the hedgehog (Hh) signaling pathway and is conserved from flies to humans. The Hh pathway plays central roles in animal development and stem-cell function. Defects in Hh signalling lead to birth defects and cancer in humans. Expressed on the primary cilium, SMO interacts with the patched protein, a receptor for Hh proteins.
