验证数据展示
经过测试的应用
| Positive WB detected in | A375 cells, K-562 cells |
Planning an IHC experiment? We recommend our IHCeasy SLC30A6/ZNT6 Ready-To-Use IHC Kit. SLC30A6/ZNT6 primary antibody included.
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2400 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
发表文章中的应用
| KD/KO | See 1 publications below |
| WB | See 7 publications below |
产品信息
13526-1-AP targets ZnT6 in WB, ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, ELISA Application Description |
| 文献引用应用 | WB |
| 经测试反应性 | human |
| 文献引用反应性 | human, mouse, chicken, Yellow catfish |
| 免疫原 | ZnT6 fusion protein Ag4403 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | solute carrier family 30 (zinc transporter), member 6 |
| 别名 | MST103, MSTP103, SLC30A6, Zinc transporter 6, ZnT 6, ZNT6 |
| 计算分子量 | 460 aa, 50 kDa |
| 观测分子量 | 51 kDa |
| GenBank蛋白编号 | BC032525 |
| 基因名称 | ZnT6 |
| Gene ID (NCBI) | 55676 |
| RRID | AB_2254797 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q6NXT4 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
ZnT6 (encoded by SLC30A6) is a member of zinc transporters. ZnT6 is localized on the membrane of the Golgi apparatus as well as cytoplasmic vesicles. It may function in transporting the cytoplasmic zinc into the Golgi apparatus as well as the vesicular compartment. Altered expression of ZnT6 may correlate to neural diseases including Alzheimer's disease. Several isoforms of ZnT6 exist due to the alternative splicing, with MW around 48-56 kDa.
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for ZnT6 antibody 13526-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |
发表文章
| Species | Application | Title |
|---|---|---|
Acta Neuropathol Commun Deregulation of subcellular biometal homeostasis through loss of the metal transporter, Zip7, in a childhood neurodegenerative disorder. | ||
J Biol Chem Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway. | ||
Metallomics Deregulation of biometal homeostasis: the missing link for neuronal ceroid lipofuscinoses? | ||
J Biol Chem Detailed analyses of the crucial functions of Zn transporter proteins in alkaline phosphatase activation.
| ||
Biochim Biophys Acta Gene Regul Mech Transcriptional responses of four slc30a/znt family members and their roles in Zn homeostatic modulation in yellow catfish Pelteobagrus fulvidraco. | ||
J Neurosci Res Zinc transporters ZnT3 and ZnT6 are downregulated in the spinal cords of patients with sporadic amyotrophic lateral sclerosis. |
