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验证数据展示

  • FC experiment of mouse bone marrow cells using 98225-1-RR (same clone as 98225-1-PBS)

    FC experiment of mouse bone marrow cells using 98225-1-RR (same clone as 98225-1-PBS)

    1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse SIRP alpha/CD172a Rabbit Recombinant Antibody (98225-1-RR, Clone: 241794D9) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were then stained with CoraLite® Plus 647 Anti-Mouse CD11b. Cells were not fixed. This data was developed using the same antibody clone with 98225-1-PBS in a different storage buffer formulation.

  • FC experiment of mouse bone marrow cells using 98225-1-RR (same clone as 98225-1-PBS)

    FC experiment of mouse bone marrow cells using 98225-1-RR (same clone as 98225-1-PBS)

    1x10^6 mouse bone marrow cells were surface stained with 0.25 ug Anti-Mouse SIRP alpha/CD172a Rabbit Recombinant Antibody (98225-1-RR, Clone: 241794D9) (red) or 0.25 ug Rabbit IgG Isotype Control Recombinant Antibody (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were not fixed. This data was developed using the same antibody clone with 98225-1-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 98225-1-RR

    Affinity and Kinetic Characterization of 98225-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98225-1-RR against Mouse SIRP Alpha/CD172a were performed. The affinity constant is below 1 pM.

Anti-Mouse SIRP Alpha/CD172a Rabbit Recombinant Antibody, PBS Only

SIRP Alpha/CD172a Uni-rAbTM Recombinant Antibody for FC
Cat No. 98225-1-PBS

产品说明书

CloneNo. 241794D9

宿主/亚型

Rabbit / IgG

种属反应性

mouse

应用

FC

别名

Inhibitory receptor SHPS-1, CD172a, CD172 antigen-like family member A, Brain Ig-like molecule with tyrosine-based activation motifs, Bit

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

98225-1-PBS targets SIRP Alpha/CD172a in FC applications and shows reactivity with mouse samples.

经测试应用 FC Application Description
经测试反应性 mouse
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 signal-regulatory protein alpha
别名 Inhibitory receptor SHPS-1, CD172a, CD172 antigen-like family member A, Brain Ig-like molecule with tyrosine-based activation motifs, Bit
计算分子量56 kDa
GenBank蛋白编号NM_007547.4
基因名称 Sirpa
Gene ID (NCBI) 19261
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP97797-2
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SIRP Alpha, also known as CD172a, SHPS-1, and BIT, belongs to the SIRP family. SIRP Alpha is a transmembrane glycoprotein expressed explicitly on myeloid cells and provides a "do not eat me" signal after engaging with integrin-associated protein CD47 on tumor cells (PMID: 36419386). SIRP Alpha shows heterogeneity in molecular weight (~65-120 kDa) in various tissues due to differential glycosylation (PMID: 18051954).