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验证数据展示

  • WB analysis of TF-1 using 60547-1-Ig (same clone as 60547-1-PBS)

    WB analysis of TF-1 using 60547-1-Ig (same clone as 60547-1-PBS)

    TF-1 cells were subjected to SDS PAGE followed by western blot with 60547-1-Ig (SIGLEC10 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60547-1-PBS in a different storage buffer formulation.

  • WB analysis of Karpas-422 using 60547-1-Ig (same clone as 60547-1-PBS)

    WB analysis of Karpas-422 using 60547-1-Ig (same clone as 60547-1-PBS)

    Karpas-422 cells were subjected to SDS PAGE followed by western blot with 60547-1-Ig (SIGLEC10 antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60547-1-PBS in a different storage buffer formulation.

SIGLEC10 Monoclonal antibody, PBS Only

SIGLEC10 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 60547-1-PBS

产品说明书

CloneNo. 2E9D7

宿主/亚型

Mouse / IgG2a

种属反应性

human

应用

WB, Indirect ELISA

别名

Siglec-10, 2E9D7, Sialic acid-binding Ig-like lectin 10, SIGLEC 10, Siglec like protein 2

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

60547-1-PBS targets SIGLEC10 in WB, Indirect ELISA applications and shows reactivity with human samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human
免疫原

CatNo: Ag20755

Product name: Recombinant human SIGLEC10 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 39-400 aa of BC101725

Sequence: VPCSFSYPRQDWTGSTPAYGYWFKAVTETTKGAPVATNHQSREVEMSTRGRFQLTGDPAKGNCSLVIRDAQMQDESQYFFRVERGSYVRYNFMNDGFFLKVTALTQKPDVYIPETLEPGQPVTVICVFNWAFEECPPPSFSWTGAALSSQGTKPTTSHFSVLSFTPRPQDHNTDLTCHVDFSRKGVSVQRTVRLRVAYAPRDLVISISRDNTPALEPQPQGNVPYLEAQKGQFLRLLCAADSQPPATLSWVLQNRVLSSSHPWGPRPLGLELPGVKAGDSGRYTCRAENRLGSQQRALDLSVQYPPENLRVMVSQANRTVLENLGNGTSLPVLEGQSLCLVCVTHSSPPARLSWTQRGQVLS

种属同源性预测
宿主/亚型 Mouse / IgG2a
抗体类别 Monoclonal
产品类型 Antibody
全称 sialic acid binding Ig-like lectin 10
别名 Siglec-10, 2E9D7, Sialic acid-binding Ig-like lectin 10, SIGLEC 10, Siglec like protein 2
计算分子量 697 aa, 77 kDa
观测分子量70-100 kDa
GenBank蛋白编号BC101725
基因名称 SIGLEC10
Gene ID (NCBI) 89790
RRIDAB_3743220
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDQ96LC7
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Sialic acid-binding Ig-like lectin 10 (SIGLEC10) is a single-pass type I membrane protein selectively expressed in the immune system, with high abundance in peripheral blood leukocytes (PMID: 11733002). Siglec-10 interacts with CD24 on innate immune cells to attenuate inflammatory responses in multiple diseases. The CD24/Siglec-10 signaling pathway is involved in cancer immunotherapy via macrophages (PMID: 38279998; 31367043).

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