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验证数据展示

  • WB analysis using 67936-1-Ig (same clone as 67936-1-PBS)

    WB analysis using 67936-1-Ig (same clone as 67936-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67936-1-Ig (SETD1A antibody) at dilution of 1:10000 and incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67936-1-PBS in a different storage buffer formulation.

  • WB analysis of HEK-293 using 67936-1-Ig (same clone as 67936-1-PBS)

    WB analysis of HEK-293 using 67936-1-Ig (same clone as 67936-1-PBS)

    WB result of SETD1A antibody (67936-1-Ig; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-SETD1A transfected HEK-293 cells. This data was developed using the same antibody clone with 67936-1-PBS in a different storage buffer formulation.

  • WB analysis of mouse brain using 67936-1-Ig (same clone as 67936-1-PBS)

    WB analysis of mouse brain using 67936-1-Ig (same clone as 67936-1-PBS)

    Mouse brain tissue was subjected to SDS PAGE followed by western blot with 67936-1-Ig (SETD1A antibody) at a dilution of 1:3000 and incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67936-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

SETD1A Monoclonal antibody, PBS Only

SETD1A Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67936-1-PBS

产品说明书

CloneNo. 1C2G12

宿主/亚型

Mouse / IgG1

种属反应性

Human, mouse, rat

应用

WB, Indirect ELISA

别名

hSET1A, KIAA0339, KMT2F, Lysine N methyltransferase 2F, SET domain containing 1A, Set1, Set1A, SETD1A

缓冲液配方:  PBS Only
PBS and Azide
PBS Only
偶联物:  Unconjugated
规格: 

-/ -

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产品信息

67936-1-PBS targets SETD1A in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 Human, mouse, rat
免疫原 SETD1A fusion protein Ag30424 种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 SET domain containing 1A
别名 hSET1A, KIAA0339, KMT2F, Lysine N methyltransferase 2F, SET domain containing 1A, Set1, Set1A, SETD1A
计算分子量 186 kDa
观测分子量270 kDa
GenBank蛋白编号NM_014712
基因名称 SETD1A
Gene ID (NCBI) 9739
RRIDAB_2918688
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein G purification
UNIPROT IDO15047
储存缓冲液 PBS only , pH 7.3
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SETD1A is a SET domain-containing methyltransferase involved in the epigenetic regulation of transcription(PMID:12670868). It is the main catalytic component of a multiprotein complex that methylates lysine 4 of histone H3, a histone mark associated with gene activation (PMID:29937342). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (PMID:31197650). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). SETD1A has a calculated molecular weight of 186 kDa, and a 258 kDa band was also reported (PMID: 31076518).