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验证数据展示

  • WB analysis using 67936-1-Ig (same clone as 67936-1-PBS)

    WB analysis using 67936-1-Ig (same clone as 67936-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67936-1-Ig (SETD1A antibody) at dilution of 1:10000 and incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67936-1-PBS in a different storage buffer formulation.

  • WB analysis of HEK-293 using 67936-1-Ig (same clone as 67936-1-PBS)

    WB analysis of HEK-293 using 67936-1-Ig (same clone as 67936-1-PBS)

    WB result of SETD1A antibody (67936-1-Ig; 1:2000; incubated at room temperature for 1.5 hours) with sh-Control and sh-SETD1A transfected HEK-293 cells. This data was developed using the same antibody clone with 67936-1-PBS in a different storage buffer formulation.

  • WB analysis of mouse brain using 67936-1-Ig (same clone as 67936-1-PBS)

    WB analysis of mouse brain using 67936-1-Ig (same clone as 67936-1-PBS)

    Mouse brain tissue was subjected to SDS PAGE followed by western blot with 67936-1-Ig (SETD1A antibody) at a dilution of 1:3000 and incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67936-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO验证

SETD1A Monoclonal antibody, PBS Only

SETD1A Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67936-1-PBS

产品说明书

CloneNo. 1C2G12

宿主/亚型

Mouse / IgG1

种属反应性

Human, mouse, rat

应用

WB, Indirect ELISA

别名

hSET1A, KIAA0339, KMT2F, Lysine N methyltransferase 2F, SET domain containing 1A, Set1, Set1A, SETD1A

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

67936-1-PBS targets SETD1A in WB, Indirect ELISA applications and shows reactivity with Human, mouse, rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 Human, mouse, rat
免疫原

CatNo: Ag30424

Product name: Recombinant human SETD1A protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-160 aa of NM_014712

Sequence: MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDGVHFSVNDSKYIPVEDLQDPRCHVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLNDNVRETFLKDMCRKYGEVEEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSV

种属同源性预测
宿主/亚型 Mouse / IgG1
抗体类别 Monoclonal
产品类型 Antibody
全称 SET domain containing 1A
别名 hSET1A, KIAA0339, KMT2F, Lysine N methyltransferase 2F, SET domain containing 1A, Set1, Set1A, SETD1A
计算分子量 186 kDa
观测分子量270 kDa
GenBank蛋白编号NM_014712
基因名称 SETD1A
Gene ID (NCBI) 9739
RRIDAB_2918688
偶联类型 Unconjugated
形式Liquid
纯化方式Protein G purification
UNIPROT IDO15047
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SETD1A is a SET domain-containing methyltransferase involved in the epigenetic regulation of transcription(PMID:12670868). It is the main catalytic component of a multiprotein complex that methylates lysine 4 of histone H3, a histone mark associated with gene activation (PMID:29937342). Responsible for H3K4me3 enriched promoters and transcriptional programming of inner mass stem cells and neuron progenitors during embryogenesis (PMID:31197650). Does not methylate 'Lys-4' of histone H3 if the neighboring 'Lys-9' residue is already methylated (PubMed:12670868). SETD1A has a calculated molecular weight of 186 kDa, and a 258 kDa band was also reported (PMID: 31076518).

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