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验证数据展示

  • WB analysis using 21170-1-AP (same clone as 21170-1-PBS)

    WB analysis using 21170-1-AP (same clone as 21170-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21170-1-AP (SERPINB7 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21170-1-PBS in a different storage buffer formulation.

  • WB analysis using 21170-1-AP (same clone as 21170-1-PBS)

    WB analysis using 21170-1-AP (same clone as 21170-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 21170-1-AP (SERPINB7 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 21170-1-PBS in a different storage buffer formulation.

SERPINB7 Polyclonal antibody, PBS Only

SERPINB7 Polyclonal Antibody for WB, Indirect ELISA
Cat No. 21170-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, Indirect ELISA

别名

Serpin B7, MEGSIN, TP55

缓冲液配方: 
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

21170-1-PBS targets SERPINB7 in WB, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag15394

Product name: Recombinant human SERPINB7 protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 32-305 aa of BC069417

Sequence: SLSLFAALALVRLGAQDDSLSQIDKLLHVNTASGYGNSSNSQSGLQSQLKRVFSDINASHKDYDLSIVNGLFAEKVYGFHKDYIECAEKLYDAKVERVDFTNHLEDTRRNINKWVENETHGKIKNVIGEGGISSSAVMVLVNAVYFKGKWQSAFTKSETINCHFKSPKCSGKAVAMMHQERKFNLSVIEDPSMKILELRYNGGINMYVLLPENDLSEIENKLTFQNLMEWTNPRRMTSKYVEVFFPQFKIEKNYEMKQYLRALGLKDIFDESKA

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 serpin peptidase inhibitor, clade B (ovalbumin), member 7
别名 Serpin B7, MEGSIN, TP55
计算分子量 380 aa, 43 kDa
观测分子量 43-45 kDa
GenBank蛋白编号BC069417
基因名称 SERPINB7
Gene ID (NCBI) 8710
RRIDAB_3742020
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDO75635
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Serine protease inhibitor B7 (SERPINB7) is also named Serpin B7, Megsin and TP55. SerpinB7 is identified as a skin-specific endogenous protease inhibitor. SerpinB7 is upregulated in diabetic nephropathy and induces progressive mesangial expansion (PMID: 11877466). SERPINB7 is abundantly expressed in keratinocytes, with particularly high levels in the stratum corneum and stratum granulosum of the epidermis (PMID: 41469525). SERPINB7 promotes keratinocyte differentiation and dampens inflammation in psoriasis in a calcium-dependent manner (PMID: 35864103). SERPINB7 is expressed mostly in renal mesangial cells, and its expression is significantly increased in renal tissues of IgA and diabetic nephropathies. SERPINB7 regulates cell proliferation, signal transduction, and extracellular matrix metabolism (PMID: 37809412).

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