验证数据展示
产品信息
13707-1-PBS targets SEPT12 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, ELISA Application Description |
| 经测试反应性 | human, mouse, rat |
| 免疫原 |
CatNo: Ag4644 Product name: Recombinant human SEPT12 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-358 aa of BC035619 Sequence: MDPLRRSPSPCLSSQPSSPSTPPCEMLGPVGIEAVLDQLKIKAMKMGFEFNIMVVGQSGLGKSTMVNTLFKSKVWKSNPPGLGVPTPQTLQLHSLTHVIEEKGVKLKLTVTDTPGFGDQINNDNCWDPILGYINEQYEQYLQEEILITRQRHIPDTRVHCCVYFVPPTGHCLRPLDIEFLQRLCRTVNVVPVIARADSLTMEEREAFRRRIQQNLRTHCIDVYPQMCFDEDINDKILNSKLRDRIPFAVVGADQEHLVNGRCVLGRKTKWGIIEVENMAHCEFPLLRDLLIRSHLQDLKDITHNIHYENYRVIRLNESHLLPRGPGWVNLAPASPGQLTTPRTFKVCRGAHDDSDDEF 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | septin 12 |
| 别名 | |
| 计算分子量 | 358 aa, 41 kDa |
| 观测分子量 | 41 kDa |
| GenBank蛋白编号 | BC035619 |
| 基因名称 | SEPT12 |
| Gene ID (NCBI) | 124404 |
| RRID | AB_3741840 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q8IYM1 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
SEPT12, also known as Septin 12, SPGF10, is a member of the Septin GTPase family. The Septin family is a group of evolutionarily conserved GTP-binding proteins involved in various cellular processes. SEPT12 is a cytoskeletal GTPase that is specifically enriched in the testis. It plays a critical role in spermatogenesis, particularly in the formation and maintenance of sperm tail structures. Mutations or downregulation of SEPT12 have been linked to male infertility due to defects in sperm morphology and function(PMID: 30513371).
