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验证数据展示

  • WB analysis using 84317-7-RR (same clone as 84317-7-PBS)

    WB analysis using 84317-7-RR (same clone as 84317-7-PBS)

    Mouse kidney tissue, rat liver tissue were subjected to SDS PAGE followed by western blot with 84317-7-RR (SEL1L antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 84317-7-PBS in a different storage buffer formulation.

  • FC experiment of MCF-7 using 84317-7-RR (same clone as 84317-7-PBS)

    FC experiment of MCF-7 using 84317-7-RR (same clone as 84317-7-PBS)

    1x10^6 MCF-7 cells were intracellularly stained with 0.25 ug SEL1L Recombinant antibody (84317-7-RR, Clone:241594G2) and APC-Conjugated Goat Anti-Rabbit IgG(H+L)(red), or 0.25 ug Isotype Control (blue). Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer. This data was developed using the same antibody clone with 84317-7-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84317-7-RR

    Affinity and Kinetic Characterization of 84317-7-RR

    Biolayer interferometry (BLl) kinetic assays of 84317-7-RR against Human SEL1L were performed. The affinity constant is 6.03 nM.

SEL1L Recombinant monoclonal antibody, PBS Only

SEL1L Uni-rAb® Recombinant Antibody for WB, FC (Intra), Indirect ELISA
Cat No. 84317-7-PBS

产品说明书

CloneNo. 241594G2

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, FC (Intra), Indirect ELISA

别名

241594G2, Protein sel 1 homolog 1, Protein sel-1 homolog 1, Sel 1L, Sel-1L

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

84317-7-PBS targets SEL1L in WB, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, FC (Intra), Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

CatNo: Ag32178

Product name: Recombinant human SEL1L protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 22-225 aa of NM_005065

Sequence: SSDEEGSQDESLDSKTTLTSDESVKDHTTAGRVVAGQIFLDSEESELESSIQEEEDSLKSQEGESVTEDISFLESPNPENKDYEEPKKVRKPALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKILNGSNKKSQKREAYRYLQKAASMNHTKALERV

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 sel-1 suppressor of lin-12-like (C. elegans)
别名 241594G2, Protein sel 1 homolog 1, Protein sel-1 homolog 1, Sel 1L, Sel-1L
计算分子量 89 kDa
观测分子量89 kDa
GenBank蛋白编号NM_005065
基因名称 SEL1L
Gene ID (NCBI) 6400
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purfication
UNIPROT IDQ9UBV2
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

SEL1L (Suppressor Enhancer Lin-12 Like) is an endoplasmic reticulum-resident transmembrane protein that plays a critical role in collagen metabolism. It has been identified as an intracellular rheostat controlling collagen turnover, which is the balance between collagen synthesis and degradation. The protein's luminal face contains a Fibronectin-2 (FN2) domain, which is known to bind collagen. SEL1L functions as a sensor of collagen biosynthesis and is necessary for the upregulation of MRC2 (mannose receptor, C-type 2), a collagen endocytic receptor that mediates the clearance of collagen. .

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