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验证数据展示

  • IHC staining of mouse brain using 55334-1-AP (same clone as 55334-1-PBS)

    IHC staining of mouse brain using 55334-1-AP (same clone as 55334-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 55334-1-AP (SCN10A/Nav1.8 antibody) at dilution of 1:400 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55334-1-PBS in a different storage buffer formulation.

  • IHC staining of rat Ischiadic nerve using 55334-1-AP (same clone as 55334-1-PBS)

    IHC staining of rat Ischiadic nerve using 55334-1-AP (same clone as 55334-1-PBS)

    Immunohistochemical analysis of paraffin-embedded rat Ischiadic nerve tissue slide using 55334-1-AP (SCN10A/Nav1.8 antibody) at dilution of 1:600 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 55334-1-PBS in a different storage buffer formulation.

  • IF Staining of SH-SY5Y using 55334-1-AP (same clone as 55334-1-PBS)

    IF Staining of SH-SY5Y using 55334-1-AP (same clone as 55334-1-PBS)

    Immunofluorescent analysis of SH-SY5Y cells using 55334-1-AP (SCN10A/Nav1.8 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L). This data was developed using the same antibody clone with 55334-1-PBS in a different storage buffer formulation.

  • FC experiment of HeLa using 55334-1-AP (same clone as 55334-1-PBS)

    FC experiment of HeLa using 55334-1-AP (same clone as 55334-1-PBS)

    1X10^6 HeLa cells were intracellularly stained with 0.4 ug Anti-Human SCN10A/Nav1.8 (55334-1-AP) and CoraLite®488-Conjugated AffiniPure Goat Anti-Rabbit IgG(H+L) at dilution 1:1000 (red), or 0.4 ug Isotype Control. Cells were fixed with 4% PFA and permeabilized with Flow Cytometry Perm Buffer. This data was developed using the same antibody clone with 55334-1-PBS in a different storage buffer formulation.

SCN10A/Nav1.8 Polyclonal antibody, PBS Only

SCN10A/Nav1.8 Polyclonal Antibody for IHC, IF/ICC, FC (Intra), Indirect ELISA
Cat No. 55334-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

IHC, IF/ICC, FC (Intra), Indirect ELISA

别名

SCN10A, hPN3, Nav1.8, PN3, SNS

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
偶联物:  Unconjugated
规格价格库存

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产品信息

55334-1-PBS targets SCN10A/Nav1.8 in IHC, IF/ICC, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 IHC, IF/ICC, FC (Intra), Indirect ELISA Application Description
经测试反应性 human, mouse, rat
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 sodium channel, voltage-gated, type X, alpha subunit
别名 SCN10A, hPN3, Nav1.8, PN3, SNS
计算分子量 221 kDa
GenBank蛋白编号NM_006514
基因名称 SCN10A
Gene ID (NCBI) 6336
RRIDAB_2881309
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDQ9Y5Y9
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Sodium channel protein type 10 subunit alpha (SCN10A, also known as Nav1.8) is predominantly expressed in neurons of the dorsal root ganglion (DRG) and trigeminal ganglion (PMID: 8538791; 9169448). Nav1.8 markedly modulates nociceptor excitability, and thereby participates in pain‑processing mechanisms (PMID: 20367448; 11495938). Furthermore, functional SCN10A/Nav1.8 has been detected in intracardiac neurons, revealing a previously unrecognized function of this neuronal sodium channel in the modulation of cardiac electrical activity (PMID: 22723301).

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