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验证数据展示

  • FC experiment of Human Bone marrow mesenchymal stromal cells using 98592-3-RR (same clone as 98592-3-PBS)

    FC experiment of Human Bone marrow mesenchymal stromal cells using 98592-3-RR (same clone as 98592-3-PBS)

    1x10^6 human bone marrow mesenchymal stromal cells were intracellularly stained with 0.25 ug Anti-Human SCF Rabbit RecAb (98592-3-RR, Clone: 250446E11) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were fixed and permeabilized with Intracellular Flow Cytometry Fixation & Permeabilization Buffer Kit (PF00019). This data was developed using the same antibody clone with 98592-3-PBS in a different storage buffer formulation.

  • FC experiment of Human Bone marrow mesenchymal stromal cells using 98592-3-RR (same clone as 98592-3-PBS)

    FC experiment of Human Bone marrow mesenchymal stromal cells using 98592-3-RR (same clone as 98592-3-PBS)

    1x10^6 human bone marrow mesenchymal stromal cells were intracellularly stained with 0.25 ug Anti-Human SCF Rabbit RecAb (98592-3-RR, Clone: 250446E11) (red) or 0.25 ug Rabbit IgG Isotype Control RecAb (98136-1-RR, Clone: 240953C9) (blue), and PE-Conjugated Goat Anti-Rabbit IgG(H+L). Cells were incubated with FC Receptor Block prior to staining. Cells were fixed and permeabilized with Intracellular Flow Cytometry Fixation & Permeabilization Buffer Kit (PF00019). This data was developed using the same antibody clone with 98592-3-PBS in a different storage buffer formulation.

Anti-Human SCF Rabbit Recombinant Antibody, PBS Only

SCF Uni-rAb® Recombinant Antibody for FC (Intra)
Cat No. 98592-3-PBS

产品说明书

CloneNo. 250446E11

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC (Intra)

别名

KITLG, c Kit ligand, c-Kit ligand, KIT ligand, Kitl

缓冲液配方:  PBS Only
PBS, Azide
PBS Only
偶联物:  Unconjugated
规格价格库存

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产品信息

98592-3-PBS targets SCF in FC (Intra) applications and shows reactivity with human samples.

经测试应用 FC (Intra) Application Description
经测试反应性 human
免疫原

CatNo:

Product name: HumanKine® recombinant human SCF protein

Source: -derived,

Tag:

Domain: of

Sequence:

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 KIT ligand
别名 KITLG, c Kit ligand, c-Kit ligand, KIT ligand, Kitl
基因名称 SCF
Gene ID (NCBI) 4254
RRIDAB_3746201
偶联类型 Unconjugated
形式Liquid
纯化方式Protein A purification
UNIPROT IDP21583
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

Stem cell factor (SCF) is also named as mast cell growth factor (MGF), Kit ligand (Kitl), c-Kit ligand, steel factor and Kitlg. SCF is a pleiotropic cytokine (also as a dimeric molecule) that mediates regulatory effects on inflammation, tissue remodeling, and fibrosis through binding to and activating its receptor tyrosine kinase c-Kit (PMID: 1698553, PMID: 8630386, PMID: 23073628). SCF is the ligand of c-Kit, a member of the RTKs family. Molecular activity of RTKs is a primary stimulus of cell motility, and expression of the SCF/c-Kit axis is associated with cell migration (PMID: 28629522). SCF is a cytokine that synergizes the effects of Epo during erythropoiesis. Stem cell factor plays a well-described role in regulating the survival, proliferation, migration, and differentiation of hematopoietic progenitors, melanocytes, and germ cells (PMID: 36688460). More recent studies have demonstrated SCF expression in dermal and intestinal epithelial cells, and increased SCF expression has been reported in the inflamed mucosa of individuals with IBD and colonitis (PMID: 18200049, PMID: 30157426).

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