验证数据展示
产品信息
66228-1-PBS targets RND3 in WB, Indirect ELISA applications and shows reactivity with human, pig samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, pig |
| 免疫原 |
CatNo: Ag18839 Product name: Recombinant human RND3 protein Source: e coli.-derived, PET28a Tag: 6*His Domain: 1-244 aa of BC012513 Sequence: MKERRASQKLSSKSIMDPNQNVKCKIVVVGDSQCGKTALLHVFAKDCFPENYVPTVFENYTASFEIDTQRIELSLWDTSGSPYYDNVRPLSYPDSDAVLICFDISRPETLDSVLKKWKGEIQEFCPNTKMLLVGCKSDLRTDVSTLVELSNHRQTPVSYDQGANMAKQIGAATYIECSALQSENSVRDIFHVATLACVNKTNKNVKRNKSQRATKRISHMPSRPELSAVATDLRKDKAKSCTVM 种属同源性预测 |
| 宿主/亚型 | Mouse / IgG2b |
| 抗体类别 | Monoclonal |
| 产品类型 | Antibody |
| 全称 | Rho family GTPase 3 |
| 别名 | ARHE, memB, Protein MemB, Rho family GTPase 3, Rho8, RhoE, RND3 |
| 计算分子量 | 244 aa, 27 kDa |
| 观测分子量 | 29 kDa |
| GenBank蛋白编号 | BC012513 |
| 基因名称 | RND3 |
| Gene ID (NCBI) | 390 |
| RRID | AB_2881619 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P61587 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Rnd3, also known as RhoE, belongs to the Rnd subclass of the Rho family of small guanosine triphosphate (GTP)-binding proteins. Rnd proteins are unique due to their inability to switch from a GTP-bound to GDP-bound conformation. The basic role of Rnd3 is to report as an endogenous antagonist of RhoA signaling-mediated actin cytoskeleton dynamics, which specifically contributes to cell migration and neuron polarity. Rnd3 also plays a critical role in arresting cell cycle distribution, inhibiting cell growth, and inducing apoptosis and differentiation.