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RCOR1 Polyclonal antibody

RCOR1 Polyclonal Antibody for WB, IHC, ELISA
Cat No. 27686-1-AP

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat

应用

WB, IHC, ELISA

RCOR 1, RCOR, COREST

缓冲液配方:  PBS and Azide
PBS and Azide
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -


经过测试的应用

Positive WB detected inC2C12 cell, PC-12 cells
Positive IHC detected inhuman ovary cancer tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

推荐稀释比

应用推荐稀释比
Western Blot (WB)WB : 1:500-1:1000
Immunohistochemistry (IHC)IHC : 1:250-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

27686-1-AP targets RCOR1 in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples.

经测试应用 WB, IHC, ELISA Application Description
文献引用应用WB, IHC
经测试反应性 human, mouse, rat
文献引用反应性human, rat
免疫原 RCOR1 fusion protein Ag26770 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 REST corepressor 1
别名 RCOR 1, RCOR, COREST
计算分子量 53 kDa
观测分子量 60-65 kDa
GenBank蛋白编号NM_015156
基因名称 RCOR1
Gene ID (NCBI) 23186
RRIDAB_2880947
偶联类型 Unconjugated
形式 Liquid
纯化方式Antigen affinity purification
储存缓冲液 PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
储存条件Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

背景介绍

RCOR1, also named as REST corepressor 1, is a 485 amino acid protein, which belongs to the CoREST family. RCOR1 is a essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. The calculated molecular weight of RCOR1 is a 53 kDa, but the phosphorylated RCOR1 is about 60-65 kDa.

实验方案

Product Specific Protocols
WB protocol for RCOR1 antibody 27686-1-APDownload protocol
IHC protocol for RCOR1 antibody 27686-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

发表文章

SpeciesApplicationTitle
humanWB

EMBO J

The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.

Authors - Buqing Ye
ratWB

Biochem Biophys Res Commun

Increased NRSF/REST in anterior cingulate cortex contributes to diabetes-related neuropathic pain.

Authors - Xu Xiao-Die
humanIHC

Ann Diagn Pathol

microRNA 155 up regulation in the CNS is strongly correlated to Down's syndrome dementia.

Authors - Esmerina Tili
humanWB

Nat Commun

Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition

Authors - Cheng Zeng
  • KO Validated
humanWB

Cell Chem Biol

HDAC3 and HDAC8 PROTAC dual degrader reveals roles of histone acetylation in gene regulation

Authors - Yufeng Xiao
humanWB

Cell Rep

E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC

Authors - Feiyu Tang
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