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验证数据展示

  • WB analysis using 16163-1-AP (same clone as 16163-1-PBS)

    WB analysis using 16163-1-AP (same clone as 16163-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 16163-1-AP (Presenilin-1-Specific antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 16163-1-PBS in a different storage buffer formulation.

  • IP experiment of mouse kidney using 16163-1-AP (same clone as 16163-1-PBS)

    IP experiment of mouse kidney using 16163-1-AP (same clone as 16163-1-PBS)

    IP result of anti-Presenilin-1-Specific (IP:16163-1-AP, 4ug; Detection:16163-1-AP 1:1000) with mouse kidney tissue lysate 4000ug. This data was developed using the same antibody clone with 16163-1-PBS in a different storage buffer formulation.

  • IHC staining of human prostate cancer using 16163-1-AP (same clone as 16163-1-PBS)

    IHC staining of human prostate cancer using 16163-1-AP (same clone as 16163-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 16163-1-AP (Presenilin-1-Specific antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16163-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with PSEN1/AD3 antibody included
  • IHC staining of mouse brain using 16163-1-AP (same clone as 16163-1-PBS)

    IHC staining of mouse brain using 16163-1-AP (same clone as 16163-1-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using 16163-1-AP (Presenilin-1-Specific antibody) at dilution of 1:1000 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16163-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with PSEN1/AD3 antibody included
  • IHC staining of human prostate cancer using 16163-1-AP (same clone as 16163-1-PBS)

    IHC staining of human prostate cancer using 16163-1-AP (same clone as 16163-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using 16163-1-AP (Presenilin-1-Specific antibody) at dilution of 1:1000 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 16163-1-PBS in a different storage buffer formulation.

    Ready-to-use IHC kits available with PSEN1/AD3 antibody included
  • Featured Product
  • KD/KO验证

Presenilin-1-Specific Polyclonal antibody, PBS Only

Presenilin-1-Specific Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 16163-1-PBS

产品说明书

宿主/亚型

Rabbit / IgG

种属反应性

human, mouse, rat, monkey

应用

WB, IHC, IP, Indirect ELISA

别名

PSEN1, AD3, EC:3.4.23.-, Presenilin-1, Presenilin-1 CTF subunit

缓冲液配方:  PBS Only
PBS, Azide, Glycerol
PBS Only
偶联物:  Unconjugated
规格价格库存

点击咨询售前客服

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Planning an IHC experiment? We recommend our IHCeasy PSEN1/AD3 Ready-To-Use IHC Kit. PSEN1/AD3 primary antibody included.

产品信息

16163-1-PBS targets Presenilin-1-Specific in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat, monkey samples.

经测试应用 WB, IHC, IP, Indirect ELISA Application Description
经测试反应性 human, mouse, rat, monkey
免疫原

Peptide

种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Polyclonal
产品类型 Antibody
全称 presenilin 1
别名 PSEN1, AD3, EC:3.4.23.-, Presenilin-1, Presenilin-1 CTF subunit
计算分子量 53 kDa
观测分子量21 kDa, 53 kDa
GenBank蛋白编号NM_000021
基因名称 PSEN1
Gene ID (NCBI) 5663
RRIDAB_2237805
偶联类型 Unconjugated
形式Liquid
纯化方式Antigen affinity purification
UNIPROT IDP49768
储存缓冲液 PBS only, pH 7.3.
储存条件Store at -80°C.
The product is shipped with ice packs. Upon receipt, store it immediately at -80°C

背景介绍

PSEN1(presenilin-1) is also named as AD3, PS1, PSNL1 and belongs to the peptidase A22A family. It directly influences Netrin/DCC signaling with cell type precision and spatiotemporal specificity, and is a key neural circuit builder that gates the spatiotemporal pattern of guidance signaling, thereby ensuring neural projections occur with high fidelity(PMID:21215373). The 46-kDa PSEN1 holoprotein is cleaved into a D30-kDa N-terminal fragment (NTF) and a D20-kDa C-terminal fragment (CTF) by the 26S proteasome (PMID:10527805). It has 7 isoforms produced by alternative splicing. This antibody is specific to isoform1(53 kDa), isoform2(52 kDa), isoform4(21 kDa), isoform7(49 kDa) of this protein.

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