验证数据展示
产品信息
87103-1-PBS targets Phospho-TAU (Thr212/Ser214) in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | microtubule-associated protein tau |
| 别名 | P TAU (Thr212/Ser214), phos TAU, Phospho TAU (Thr212/Ser214), Phospho-TAU Thr212/Ser214, phos-TAU |
| 计算分子量 | 37-46, 79-81 kDa |
| 观测分子量 | 45-60 kDa |
| GenBank蛋白编号 | BC000558 |
| 基因名称 | TAU |
| Gene ID (NCBI) | 4137 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P10636 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
The double phosphorylation of Tau at Thr212/Ser214 is a hallmark of Alzheimer's disease neurofibrillary tangles. This modification is critical for inducing a pathological conformation that promotes Tau aggregation into toxic filaments while impairing its normal microtubule-stabilizing function.
