验证数据展示
产品信息
87096-1-PBS targets Phospho-HER2/ErbB2 (Tyr1248) in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) |
| 别名 | ErbB2 (phospho-Y1248), HER2 (phospho-Y1248), p-ErbB2 Y1248, p-HER2 Y1248, Phospho-ErbB2 |
| 计算分子量 | 1255 aa, 138 kDa |
| 观测分子量 | 185 kDa |
| GenBank蛋白编号 | BC156755 |
| 基因名称 | HER2/ErbB2 |
| Gene ID (NCBI) | 2064 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P04626 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. Phospho-HER2/ErbB2 (Tyr1248) is a phosphorylated form of the HER2 protein, which is a member of the epidermal growth factor receptor (EGFR) family. This phosphorylation event is considered a prerequisite for HER2 signaling and its transforming activity. The phosphorylation of HER2 at Tyr1248 residue is a key step in the activation of downstream signaling cascades that regulate various cellular processes, including cell growth, proliferation, and survival. Tyrosine 1248 is the main autophosphorylation site in the carboxy terminal domain of ErbB2 linked to downstream signaling through the ras-raf-MEK-p42/44 MAPK signal transduction pathway. (PMID: 19084911)
