验证数据展示
产品信息
85242-1-PBS targets Phospho-FRS2 (Tyr436) in WB, Indirect ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | fibroblast growth factor receptor substrate 2 |
| 别名 | P FRS2 (Tyr436), P-FRS2 (Tyr436), Phos FRS2 (Tyr436), Phos-FRS2 (Tyr436), Phospho-FRS2-α (Tyr436) |
| 计算分子量 | 60 kDa |
| 观测分子量 | 80-85 kDa |
| GenBank蛋白编号 | BC021562 |
| 基因名称 | FRS2 |
| Gene ID (NCBI) | 10818 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q8WU20 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Fibroblast growth factor substrate 2 (FRS2), a lipid-anchored docking protein that is phosphorylated upon activation of FGFR, is critical for recruitment of downstream signaling molecules and links the FGFRs to the Ras/Mek/Erk pathway and the PI3-Kinase/Akt pathway. Studies have found that the phosphotyrosine binding domain of FRS-2 directly binds the Trk receptors at the same phosphotyrosine residue that binds the signaling adapter Shc, suggesting a model in which competitive binding between FRS-2 and Shc regulates differentiation versusproliferation. (PMID: 19053057, PMID: 10092678)
