验证数据展示
产品信息
87084-2-PBS targets Phospho-EGFR (Tyr1110) in WB, Indirect ELISA applications and shows reactivity with human samples.
| 经测试应用 | WB, Indirect ELISA Application Description |
| 经测试反应性 | human |
| 免疫原 |
Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) |
| 别名 | p-EGF Receptor, p-EGF Receptor (Tyr1086), p-EGFR (Tyr1086), p-EGFR (Tyr1110), p-EGFR Y1086 |
| 计算分子量 | 1210 aa, 134 kDa |
| 观测分子量 | 175 kDa |
| GenBank蛋白编号 | BC094761 |
| 基因名称 | EGFR |
| Gene ID (NCBI) | 1956 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | P00533 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
EGFR is a receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Phospho-EGFR (Tyr1110) is the phosphorylated, active form of the epidermal growth factor receptor (EGFR) at tyrosine 1110 within the C-terminal tail. This modification is catalyzed by EGFR itself or SRC-family kinases upon ligand (EGF, TGF-α) binding or oxidative stress. Phosphorylation at Tyr1110 creates a docking site for SH2-domain-containing proteins, propagating downstream signals through the RAS-RAF-MEK-ERK and PI3K-AKT pathways. Some scientists call EGFR Tyr1110 as EGFR Tyr1086, the site where the signaling peptide is removed.
