验证数据展示
发表文章中的应用
| WB | See 1 publications below |
产品信息
15982-1-AP targets PUM1 in WB, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | ELISA Application Description |
| 文献引用应用 | WB |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human |
| 免疫原 | PUM1 fusion protein Ag8790 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | pumilio homolog 1 (Drosophila) |
| 别名 | HSPUM, KIAA0099, PUM1, PUMH, PUMH1, Pumilio 1, Pumilio homolog 1, pumilio homolog 1 (Drosophila), PUML1 |
| 计算分子量 | 1186 aa, 126 kDa |
| GenBank蛋白编号 | BC013398 |
| 基因名称 | PUM1 |
| Gene ID (NCBI) | 9698 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | Q14671 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
PUM1, also named as PUMH1, PUML1 and Pumilio 1, is a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. This protein contains one PUM-HD domain and eight pumilio repeats. It is a sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. It is strongly downregulated in keratinocytes upon UVB irradiation. The human PUM1 protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. It may be required to support proliferation and self-renewal of stem cells. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human PUM1.